| Single-molecule view of coordination in a multi-functional DNA polymerase. | Single-molecule view of coordination in a multi-functional DNA polymerase.
Pauszek RF 3rd, Lamichhane R, Rajkarnikar Singh A, Millar DP., Free PMC Article | 12/11/2021 |
| E. coli DNA Polymerase I and the Klenow Fragment. | E. coli DNA Polymerase I and the Klenow Fragment.
Green MR, Sambrook J. | 05/22/2021 |
| Findings indicate an unrealized function of DNA polymerase I (Pol I), and a possible mechanism by which G4 structures can be resolved during DNA replication and/or repair. | Escherichia coli DNA polymerase I can disrupt G-quadruplex structures during DNA replication.
Teng FY, Hou XM, Fan SH, Rety S, Dou SX, Xi XG. | 12/30/2017 |
| Authors demonstrate for the first time that the major DNA polymerases (Pol I and Pol III) and DNA ligase are directly involved with oligo recombination. | Bacterial DNA polymerases participate in oligonucleotide recombination.
Li XT, Thomason LC, Sawitzke JA, Costantino N, Court DL., Free PMC Article | 12/21/2013 |
| Pol I catalyzes DNA synthesis past N6-dA-linked peptide cross-links and is likely to play an role in cellular bypass of large major groove DNA lesions. | Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link.
Yamanaka K, Minko IG, Finkel SE, Goodman MF, Lloyd RS., Free PMC Article | 10/1/2011 |
| analysis of complexes of DNA polymerase I (Klenow fragment) for base and sugar discrimination during nucleotide substrate selection | Distinct complexes of DNA polymerase I (Klenow fragment) for base and sugar discrimination during nucleotide substrate selection.
Garalde DR, Simon CA, Dahl JM, Wang H, Akeson M, Lieberman KR., Free PMC Article | 07/2/2011 |
| Data show that dnaX36 strains have an increased requirement for DNA polymerase I. | Role of accessory DNA polymerases in DNA replication in Escherichia coli: analysis of the dnaX36 mutator mutant.
Gawel D, Pham PT, Fijalkowska IJ, Jonczyk P, Schaaper RM., Free PMC Article | 01/21/2010 |
| Findings indicate that elevated levels of Pol I partially suppress the temperature-sensitive growth phenotype of the dnaN159 mutant strain. | Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain.
Maul RW, Sanders LH, Lim JB, Benitez R, Sutton MD., Free PMC Article | 01/21/2010 |
| mechanism in which Arg668 forms a hydrogen bonding fork between the minor groove of the primer terminus and the ring oxygen of the deoxyribose moiety of the incoming dNTP to align the 3'-hydroxyl group with the alpha-phosphate of the dNTP | Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli.
McCain MD, Meyer AS, Schultz SS, Glekas A, Spratt TE. | 01/21/2010 |
| mutant(Delta)polA is defective in base mismatch correction | Escherichia coli mutator (Delta)polA is defective in base mismatch correction: the nature of in vivo DNA replication errors.
Tago Y, Imai M, Ihara M, Atofuji H, Nagata Y, Yamamoto K. | 01/21/2010 |
| a new in vivo function for wild-type DNA polymerase I in chromosome termination at site(s) not yet identified is proposed | A new in vivo termination function for DNA polymerase I of Escherichia coli K12.
Markovitz A. | 01/21/2010 |
| analysis of amino acid substitutions that increase the fidelity of Escherichia coli DNA polymerase I | Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.
Loh E, Choe J, Loeb LA. | 01/21/2010 |
| Glutamine677 is perhaps the first residue in the pol I family of enzymes that is shown to be essential for the functioning of both polymerase and proofreading activities. | Contribution of polar residues of the J-helix in the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch.
Singh K, Modak MJ. | 01/21/2010 |