| Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. | Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Shi J, Wang L, Wen A, Wang F, Zhang Y, Yu L, Li F, Jin Y, Feng Z, Li J, Yang Y, Gao F, Zhang Y, Feng Y, Wang S, Zhao W, Lin W., Free PMC Article | 11/12/2022 |
| PCR analysis of RNA from the wild-type, DeltaacrR, and acrR (+) strains showed that AcrR represses the transcription of marRAB and soxRS, and its own gene cluster, acrRAB. | Overproduction of AcrR increases organic solvent tolerance mediated by modulation of SoxS regulon in Escherichia coli.
Lee JO, Cho KS, Kim OB. | 06/20/2015 |
| Genetic defects in SoxS, MarA, or AcrB underlie superoxide-mediated protection of Escherichia coli from antimicrobials. | Superoxide-mediated protection of Escherichia coli from antimicrobials.
Mosel M, Li L, Drlica K, Zhao X., Free PMC Article | 05/17/2014 |
| In this study, microarrays and RT-PCR analysis were used to show the overexpression of the ompN porin and its upstream gene, ydbK, in an Escherichia coli multidrug-resistant mutant and in a strain constitutive for SoxS. | SoxS-dependent coregulation of ompN and ydbK in a multidrug-resistant Escherichia coli strain.
Fàbrega A, Rosner JL, Martin RG, Solé M, Vila J. | 12/29/2012 |
| There is a transient change in the activity of the iron regulator Fur and of the oxidative stress regulator SoxS after Zn addition. | Dynamics of a starvation-to-surfeit shift: a transcriptomic and modelling analysis of the bacterial response to zinc reveals transient behaviour of the Fur and SoxS regulators.
Graham AI, Sanguinetti G, Bramall N, McLeod CW, Poole RK. | 04/21/2012 |
| This work implicates SoxS control of znuCB expression as a key factor in persistence of Escherichia coli in murine pyelonephritis. | SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model.
Warner DM, Levy SB., Free PMC Article | 03/31/2012 |
| The results indicate that activation of the soxRS regulon in E. coli cells exposed to superoxide-propagating compounds can be triggered by depletion of the NADPH stock rather than accumulation of superoxide itself. | The soxRS response of Escherichia coli can be induced in the absence of oxidative stress and oxygen by modulation of NADPH content.
Krapp AR, Humbert MV, Carrillo N. | 12/31/2011 |
| Genetic evidence for a novel interaction between transcriptional activator soxs and region 4 of the sigma(70) subunit of RNA polymerase at class ii SoxS-dependent promoters in Escherichia coli | Genetic evidence for a novel interaction between transcriptional activator SoxS and region 4 of the σ(70) subunit of RNA polymerase at class II SoxS-dependent promoters in Escherichia coli.
Zafar MA, Sanchez-Alberola N, Wolf RE Jr., Free PMC Article | 06/25/2011 |
| SoxS is now the first example of an E. coli transcriptional activator that uses a single positive control surface to make specific protein-protein contacts with two different subunits of RNAP. | Protein-protein interactions between sigma(70) region 4 of RNA polymerase and Escherichia coli SoxS, a transcription activator that functions by the prerecruitment mechanism: evidence for "off-DNA" and "on-DNA" interactions.
Zafar MA, Shah IM, Wolf RE Jr., Free PMC Article | 08/16/2010 |
| roles of the Escherichia coli transcriptional regulators MarA, SoxS and Rob in susceptibility to cationic antimicrobial peptides | Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.
Warner DM, Levy SB., Free PMC Article | 05/3/2010 |
| Data that TolC is involved in the efflux of certain cellular metabolites that accumulate during growth and trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites. | An excretory function for the Escherichia coli outer membrane pore TolC: upregulation of marA and soxS transcription and Rob activity due to metabolites accumulated in tolC mutants.
Rosner JL, Martin RG., Free PMC Article | 01/21/2010 |
| The authors show here that tolC has two additional strong overlapping promoters, p3 and p4, which are downstream of p1, p2 and the marbox and are activated by MarA, SoxS and Rob. | Transcriptional activation by MarA, SoxS and Rob of two tolC promoters using one binding site: a complex promoter configuration for tolC in Escherichia coli.
Zhang A, Rosner JL, Martin RG., Free PMC Article | 01/21/2010 |
| Results describe the activation of the Escherichia coli marA/soxS/rob regulon in response to transcriptional activator concentration. | Activation of the Escherichia coli marA/soxS/rob regulon in response to transcriptional activator concentration.
Martin RG, Bartlett ES, Rosner JL, Wall ME., Free PMC Article | 01/21/2010 |
| N-terminus verified by Edman degradation on mature peptide | SoxS, an activator of superoxide stress genes in Escherichia coli. Purification and interaction with DNA.
Li Z, Demple B. | 11/5/2007 |
| Data show that expression of TetD activates transcription of a subset of the SoxS/MarA/Rob regulon genes and confers resistance to redox-cycling compounds and antibiotics. | Characterization of TetD as a transcriptional activator of a subset of genes of the Escherichia coli SoxS/MarA/Rob regulon.
Griffith KL, Becker SM, Wolf RE Jr. | 01/21/2010 |
| soxS DNA binding mutations are dominant to the wild-type allele | Genetic evidence for pre-recruitment as the mechanism of transcription activation by SoxS of Escherichia coli: the dominance of DNA binding mutations of SoxS.
Griffith KL, Wolf RE Jr. | 01/21/2010 |
| Data show that SoxS diverts RNA polymerase alpha from UP-containing promoters to SoxS-activatable promoters | Novel protein--protein interaction between Escherichia coli SoxS and the DNA binding determinant of the RNA polymerase alpha subunit: SoxS functions as a co-sigma factor and redeploys RNA polymerase from UP-element-containing promoters to SoxS-dependent promoters during oxidative stress.
Shah IM, Wolf RE Jr. | 01/21/2010 |
| We found that the addition of soxbox DNA or RNA polymerase to an in vitro degradation system decreases the rate of SoxS proteolysis by Lon protease. | Inhibition of Lon-dependent degradation of the Escherichia coli transcription activator SoxS by interaction with 'soxbox' DNA or RNA polymerase.
Shah IM, Wolf RE Jr. | 01/21/2010 |