GDF-15 and mtDNA Deletions Are Useful Biomarkers of Mitochondrial Dysfunction in Insulin Resistance and PCOS.
Varhegyi V, Modos A, Trager D, Gerszi D, Horvath EM, Sipos M, Acs N, Molnar MJ, Varbiro S, Gal A., Free PMC Article

Identification and characterization of human GDF15 knockouts.
Gurtan AM, Khalid S, Koch C, Khan MZ, Lamarche LB, Splawski I, Dolan E, Carrion AM, Zessis R, Clement ME, Chen Z, Lindsley LD, Chiu YH, Streeper RS, Denning DP, Goldfine AB, Doyon B, Abbasi A, Harrow JL, Tsunoyama K, Asaumi M, Kou I, Shuldiner AR, Rodriguez-Flores JL, Rasheed A, Jahanzaib M, Mian MR, Liaqat MB, Raza SS, Sultana R, Jalal A, Saeed MH, Abbas S, Memon FR, Ishaq M, Dominy JE, Saleheen D.

The implicated role of GDF15 in gastrointestinal cancer.
Xue Y, Zhang Y, Su Y, Zhao J, Yu D, Jo Y, Joo J, Lee HJ, Ryu D, Wei S.

Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells.
Rampazzo Morelli N, Préfontaine C, Pipella J, Thompson PJ.,

GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer.
Lin H, Luo Y, Gong T, Fang H, Li H, Ye G, Zhang Y, Zhong M.

Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z, Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S., Free PMC Article

METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination.
Gu X, Song Y, Liu X, Cheng Z, Min J, Zhang Y.

Growth differentiation factor 15: Emerging role in liver diseases.
Li Y, Zhang J, Chen S, Ke Y, Li Y, Chen Y.

NR2F1 overexpression alleviates trophoblast cell dysfunction by inhibiting GDF15/MAPK axis in preeclampsia.
Zhang K, Zhang H, Wang B, Gao S, Sun C, Jia C, Cui J.

Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age-dependent fashion and induces cell senescence via GDF15.
Chiariello A, Rossetti L, Valente S, Pasquinelli G, Sollazzo M, Iommarini L, Porcelli AM, Tognocchi M, Conte G, Santoro A, Kwiatkowska KM, Garagnani P, Salvioli S, Conte M., Free PMC Article

Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes.
Billeson K, Baldimtsi E, Wahlberg J, Whiss PA., Free PMC Article

MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage.
Shi JX, Yang L, Gan J, Gu WW, Gu Y, Shi Y, Jiang HY, Xu HR, Yang SH, Zhang X, Wang J.

Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 Diabetes.
Sabaratnam R, Kristensen JM, Pedersen AJT, Kruse R, Handberg A, Wojtaszewski JFP, Højlund K.

GDF15 Interference Regulates Proliferation, Inflammation, and Autophagy of Lipopolysaccharide-induced Mesangial Cells by Inhibiting PI3K/ AKT/mTOR Signaling.
Chen Z, Gao L, Li C, Sun W.

Growth differentiation factor 15 and malnutrition in older adults.
Rostami N, Fabre-Estremera B, Buño-Soto A, Banegas JR, Rodríguez-Artalejo F, Ortolá R.

Total and H-specific GDF-15 levels increase in caloric deprivation independently of leptin in humans.
Chrysafi P, Valenzuela-Vallejo L, Stefanakis K, Kelesidis T, Connelly MA, Mantzoros CS., Free PMC Article

Hyperactive behaviour of growth differentiation factor- 15 (GDF-15) in conjunction with iron trafficking transporters and suppression of Nrf-2 gene in diabetes and metabolic syndrome.
Saroj M, Prakash S, Vikram NK, Saraya A, Priyatma, Ganie MA, Arulselvi S, Pandey S.

Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease.
Nyárády BB, Kiss LZ, Bagyura Z, Merkely B, Dósa E, Láng O, Kőhidai L, Pállinger É.

Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.
Shah FA, Bahudhanapati H, Jiang M, Tabary M, van der Geest R, Tolman NJ, Kochin M, Xiong Z, Al-Yousif N, Sayed K, Benos PV, Raffensperger K, Evankovich J, Neal MD, Snyder ME, Eickelberg O, Ray P, Dela Cruz C, Bon J, McVerry BJ, Straub AC, Jurczak MJ, Suber TL, Zhang Y, Chen K, Kitsios GD, Lee JS, Alder JK, Bain WG., Free PMC Article

GDF15 as a key disease target and biomarker: linking chronic lung diseases and ageing.
Wan Y, Fu J., Free PMC Article

Evaluation of the relationship between atherosclerosis and Helicobacter pylori infection with measurement of growth differentiation factor 15 and atherosclerosis indicators in adults with no comorbidity.
Başpinar O, Elibol A, Koçer D, Tokmak TT, Doğan S, Dizdar OS.

TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis.
Liuizė Abramavičiūtė A, Mongirdienė A., Free PMC Article

Incremental values of AOPP, IL-6, and GDF15 for identifying arteriosclerosis in patients with obstructive sleep apnea.
Li X, Liu W, Wang Y, Zhao C, Zhu Q, Dong Z, Ma C., Free PMC Article

GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.
Asundi J, Zhang C, Donnelly-Roberts D, Solorio JZ, Challagundla M, Connelly C, Boch C, Chen J, Richter M, Maneshi MM, Swensen AM, Lebon L, Schiffmann R, Sanyal S, Sidrauski C, Kolumam G, Baruch A., Free PMC Article

GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex.
Xie B, Tang W, Wen S, Chen F, Yang C, Wang M, Yang Y, Liang W., Free PMC Article