| RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway. | RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway.
Hua H, Xie H, Zheng J, Lei L, Deng Z, Yu C., Free PMC Article | 01/21/2023 |
| RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop. | RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop.
Xiao C, Zhang W, Hua M, Chen H, Yang B, Wang Y, Yang Q., Free PMC Article | 05/21/2022 |
| We demonstrated that RNF7 knockdown induced growth suppression of prostate cancer cells and inactivated ERK1/2 pathway, which suggested RNF7 might be a potential novel therapeutic target for CRPC. | RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway.
Xiao Y, Jiang Y, Song H, Liang T, Li Y, Yan D, Fu Q, Li Z., Free PMC Article | 11/10/2018 |
| Results identified RNF7 to interact with CARMA2 regulating its NF-kappaB-activating capacity. Mechanistically, RNF7 influences CARMA2 signaling by regulating the ubiquitination state of MALT1 and the NF-kappaB-regulatory molecule NEMO. | The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling.
Telesio G, Scudiero I, Pizzulo M, Mazzone P, Zotti T, Voccola S, Polvere I, Vito P, Stilo R., Free PMC Article | 07/14/2018 |
| This is the first report on a diagnostic test for simultaneous genotyping of IFNL3, ABCB11, and RNF7 in Chronic hepatitis C (CHC) patients. Reliable and inexpensive, the assay should provide useful information for the clinical management of CHC, like identification of patients at risk of rapid disease progression or with high chances of response to classic therapy. | Triplex High-Resolution Melting Assay for the Simultaneous Assessment of IFNL3 rs12979860, ABCB11 rs2287622, and RNF7 rs16851720 Genotypes in Chronic Hepatitis C Patients.
Enache EL, Sin A, Enache LS, Bancu L. | 06/9/2018 |
| Sag is a Kras-cooperating oncogene that promotes lung tumorigenesis | Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
Li H, Tan M, Jia L, Wei D, Zhao Y, Chen G, Xu J, Zhao L, Thomas D, Beer DG, Sun Y., Free PMC Article | 05/31/2018 |
| NEDD4-1 overexpression sensitizes cancer cells to etoposide-induced apoptosis by reducing SAG levels through targeted degradation. SAG is added to a growing list of NEDD4-1 substrates and mediates its biological function. | SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.
Zhou W, Xu J, Zhao Y, Sun Y., Free PMC Article | 05/31/2018 |
| SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S ubiquitin-conjugating enzymes to ubiquitylate beta-TrCP1 via K11-linkage for degradation. | SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.
Kuang P, Tan M, Zhou W, Zhang Q, Sun Y., Free PMC Article | 05/19/2018 |
| RNF7 gene variant is associated with the risk of developing liver fibrosis and cirrhosis in an Eastern European population. | PNPLA3 and RNF7 Gene Variants are Associated with the Risk of Developing Liver Fibrosis and Cirrhosis in an Eastern European Population.
Kupcinskas J, Valantiene I, Varkalaitė G, Steponaitiene R, Skieceviciene J, Sumskiene J, Petrenkiene V, Kondrackiene J, Kiudelis G, Lammert F, Kupcinskas L. | 09/9/2017 |
| MAF1, RNF7 and SETD3 are identified as PCNA-associated proteins in human cells and given this interaction with PCNA, Maf1, RNF7, and SetD3 are potentially involved in DNA replication, DNA repair, or associated processes. | A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells.
Cooper SE, Hodimont E, Green CM., Free PMC Article | 05/21/2016 |
| These findings indicate that Rbx1 and Rbx2 can both activate Cul5-Vif E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo. | Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro.
Wang X, Wang X, Wang W, Zhang J, Wang J, Wang C, Lv M, Zuo T, Liu D, Zhang H, Wu J, Yu B, Kong W, Wu H, Yu X. | 08/1/2015 |
| Single nucleotide polymorphism rs16851720 was associated with liver fibrosis progression. | Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
Patin E, Kutalik Z, Guergnon J, Bibert S, Nalpas B, Jouanguy E, Munteanu M, Bousquet L, Argiro L, Halfon P, Boland A, Müllhaupt B, Semela D, Dufour JF, Heim MH, Moradpour D, Cerny A, Malinverni R, Hirsch H, Martinetti G, Suppiah V, Stewart G, Booth DR, George J, Casanova JL, Bréchot C, Rice CM, Talal AH, Jacobson IM, Bourlière M, Theodorou I, Poynard T, Negro F, Pol S, Bochud PY, Abel L, Swiss Hepatitis C Cohort Study Group, International Hepatitis C Genetics Consortium, French ANRS HC EP 26 Genoscan Study Group., Free PMC Article | 01/26/2013 |
| Data suggest that the sensitive-to-apoptosis gene may be a candidate gene for good prognosis in rectal cancer, independent of therapeutic response of different individuals. | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer.
Ozden SA, Ozyurt H, Ozgen Z, Kilinc O, Oncel M, Gul AE, Karadayi N, Serakinci N, Kan B, Orun O., Free PMC Article | 02/25/2012 |
| SAG plays an important role in regulating ionizing radiation-induced apoptosis | Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis.
Kim SY, Yang ES, Lee YS, Lee J, Park JW. | 04/23/2011 |
| The findings showed that SAG E3 ubiquitin ligase plays an essential role in cancer cell proliferation and tumor growth | Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target.
Jia L, Yang J, Hao X, Zheng M, He H, Xiong X, Xu L, Sun Y., Free PMC Article | 05/3/2010 |
| Sensitive to apoptosis gene may play an important role in regulating the apoptosis induced by heat shock presumably through maintaining the cellular redox status. | Regulation of heat shock-induced apoptosis by sensitive to apoptosis gene protein.
Lee SJ, Yang ES, Kim SY, Kim SY, Shin SW, Park JW. | 01/21/2010 |
| Promotes hypoxia-inducible factor 1 alpha subunit (HIF-1 alpha) ubiquitination and degradation. | SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation.
Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. | 01/21/2010 |
| results indicate that protein kinase CKII may control IkappaBalpha and p27Kip1 degradation and thereby G1/S phase transition through the phosphorylation of threonine 10 within CKBBP1 protein | Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.
Kim YS, Lee JY, Son MY, Park W, Bae YS. | 01/21/2010 |
| These studies suggested that CK2 might regulate SAG-SCF E3 ligase activity through modulating SAG's stability, rather than its enzymatic activity directly. | CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.
He H, Tan M, Pamarthy D, Wang G, Ahmed K, Sun Y. | 01/21/2010 |
| SAG possesses a potent peroxidase property to decompose hydrogen peroxide in the presence of dithiothreitol | Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein.
Kim SY, Bae YS, Park JW. | 01/21/2010 |
| sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage. | Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage.
Kim SY, Lee JH, Yang ES, Kil IS, Park JW. | 01/21/2010 |
| results show that the Ring-H2 finger motif of CKBBP1 is necessary for efficient binding to CKIIbeta, as well as for optimal cell proliferation | The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation.
Kim YS, Ha KS, Kim YH, Bae YS. | 01/21/2010 |
| Endogenous levels of pro-caspase 3 were decreased by overexpression of SAG protein. | SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.
Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y., Free PMC Article | 01/21/2010 |