| RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21. | RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.
Sengar AS, Kumar M, Rai C, Chakraborti S, Kumar D, Kumar P, Mukherjee S, Mondal K, Stewart A, Maity B., Free PMC Article | 02/29/2024 |
| RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4. | RGS6 suppresses TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4.
Wang Z, Chen J, Wang S, Sun Z, Lei Z, Zhang HT, Huang J., Free PMC Article | 08/13/2022 |
| Age-dependent nigral dopaminergic neurodegeneration and alpha-synuclein accumulation in RGS6-deficient mice. | Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.
Luo Z, Ahlers-Dannen KE, Spicer MM, Yang J, Alberico S, Stevens HE, Narayanan NS, Fisher RA., Free PMC Article | 09/19/2020 |
| the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo. | The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells.
Guo YX, Xu YH, Zheng GH, Jin XQ. | 04/28/2018 |
| study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6 | HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6.
Li S, Jin X, Wu H, Wang Y, Li X, Guo Y, Liang S., Free PMC Article | 10/21/2017 |
| genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied. | Interaction between the RGS6 gene and psychosocial stress on obesity-related traits.
Kim HJ, Min JY, Min KB. | 10/7/2017 |
| Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities. | Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
Jeon JP, Thakur DP, Tian JB, So I, Zhu MX., Free PMC Article | 05/20/2017 |
| Our results suggest that HA117 is a strong multidrug resistance gene. | Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1.
Zhao L, Sun Y, Li X, Jin X, Xu Y, Guo Z, Liang R, Ding X, Chen T, Wang S. | 03/15/2017 |
| This suggests that HA117 might be an important resistance gene in pediatric solid tumors. | Expression of the novel all-trans retinoic acid-related resistance gene HA117 in pediatric solid tumors.
Duan W, Jin X, Xiu Y, Wang S, Zhu J, Liu H, Ding X, Jin X, Zhao Z, Wang X. | 08/4/2016 |
| No significant association between SNPs of RGS6 and central adiposity has been found. | A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.
Kim HJ, Park JH, Lee S, Son HY, Hwang J, Chae J, Yun JM, Kwon H, Kim JI, Cho B., Free PMC Article | 05/21/2016 |
| reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker | Prognostic value of regulator of G-protein signaling 6 in colorectal cancer.
Luo Y, Qin SL, Yu MH, Mu YF, Wang ZS, Zhong M. | 04/16/2016 |
| these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target. | Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients.
Jiang N, Xue R, Bu F, Tong X, Qiang J, Liu R., Free PMC Article | 05/16/2015 |
| we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes. | RGS6: a novel gene associated with congenital cataract, mental retardation, and microcephaly in a Tunisian family.
Chograni M, Alkuraya FS, Maazoul F, Lariani I, Chaabouni-Bouhamed H. | 03/28/2015 |
| genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype | RGS6 variants are associated with dietary fat intake in Hispanics: the IRAS Family Study.
Sibbel SP, Talbert ME, Bowden DW, Haffner SM, Taylor KD, Chen YD, Wagenknecht LE, Langefeld CD, Norris JM., Free PMC Article | 11/12/2011 |
| RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins | Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity.
Maity B, Yang J, Huang J, Askeland RW, Bera S, Fisher RA., Free PMC Article | 03/5/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesA Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. A functional polymorphism in RGS6 modulates the risk of bladder cancer.
Berman DM, Wang Y, Liu Z, Dong Q, Burke LA, Liotta LA, Fisher R, Wu X. | 03/13/2008 |
| RGS6 is the first member of the RGS protein family shown to interact with proteins involved in transcriptional regulation. | RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.
Liu Z, Fisher RA. | 01/21/2010 |
| interacts with SCG10 and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of this protein | RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.
Liu Z, Chatterjee TK, Fisher RA. | 01/21/2010 |
| RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants | Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants.
Chatterjee TK, Liu Z, Fisher RA. | 01/21/2010 |
| Role of the RGS domain in stress-induced trafficking of RGS6 protein | Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.
Chatterjee TK, Fisher RA. | 01/21/2010 |