| this genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption | A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.
Haaland ØA, Romanowska J, Gjerdevik M, Lie RT, Gjessing HK, Jugessur A., Free PMC Article | 06/20/2020 |
| Treatment of ARHGEF10-depleted cells with the inhibitor dasatinib reduced levels of phospho Src kinase and attenuated motility and invasion in vitro. Together, our data indicate that ARHGEF10 may function as a tumor suppressor in Pancreatic ductal adenocarcinoma (PDAC). | Rho guanine nucleotide exchange factor ARHGEF10 is a putative tumor suppressor in pancreatic ductal adenocarcinoma.
Joseph J, Radulovich N, Wang T, Raghavan V, Zhu CQ, Tsao MS. | 04/18/2020 |
| it was suggested that ARHGEF10 is involved in the regulation of Rab6A and Rab8A localization and invasion of breast carcinoma cells, in which Rab8 also acts via regulation of membrane trafficking. | Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
Shibata S, Teshima Y, Niimi K, Inagaki S., Free PMC Article | 04/11/2020 |
| A single nucleotide polymorphisms (SNPs) associated with higher delta-6 desaturase (D6D) activity within the Rho guanine nucleotide exchange factor 10 (ARHGEF10) gene is potentially altering plasma triglyceride levels. | A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.
de Toro-Martín J, Guénard F, Rudkowska I, Lemieux S, Couture P, Vohl MC. | 09/21/2019 |
| Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. | ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.
Shibata S, Kawanai T, Hara T, Yamamoto A, Chaya T, Tokuhara Y, Tsuji C, Sakai M, Tachibana T, Inagaki S. | 08/5/2017 |
| This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population. | ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population.
Li H, Yu S, Wang R, Sun Z, Zhou X, Zheng L, Yin Z, Zhang X, Sun Y. | 01/28/2017 |
| A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found. | Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance).
Boora GK, Kulkarni AA, Kanwar R, Beyerlein P, Qin R, Banck MS, Ruddy KJ, Pleticha J, Lynch CA, Behrens RJ, Züchner S, Loprinzi CL, Beutler AS., Free PMC Article | 09/17/2016 |
| Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). | Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).
Chaya T, Shibata S, Tokuhara Y, Yamaguchi W, Matsumoto H, Kawahara I, Kogo M, Ohoka Y, Inagaki S., Free PMC Article | 10/22/2011 |
| the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population | The functional SNP rs4376531 in the ARHGEF gene is a risk factor for the atherothrombotic stroke in Han Chinese.
Yin YY, Zhang B, Zhou MK, Guo J, Lei L, He XH, Xu YM, He L. | 09/10/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The functional single-nucleotide polymorphism of ARHGEF10 confers the susceptibility to atherothrombotic stroke. | Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.
Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M, Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M. | 06/14/2010 |
| A novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. | Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Aoki T, Ueda S, Kataoka T, Satoh T., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesFunctional SNP of ARHGEF10 confers risk of atherothrombotic stroke.
Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M, Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.
Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ. | 03/13/2008 |
| data support a role for ARHGEF10 in developmental myelination of peripheral nerves | Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.
Verhoeven K, De Jonghe P, Van de Putte T, Nelis E, Zwijsen A, Verpoorten N, De Vriendt E, Jacobs A, Van Gerwen V, Francis A, Ceuterick C, Huylebroeck D, Timmerman V., Free PMC Article | 01/21/2010 |
| Gef10 is the third member of a Rho-specific GEF family with unusual protein architecture | Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture.
Mohl M, Winkler S, Wieland T, Lutz S. | 01/21/2010 |