| A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models. | A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models.
Hall A, Middlehurst B, Cadogan MAM, Reed X, Billingsley KJ, Bubb VJ, Quinn JP., Free PMC Article | 02/5/2024 |
| LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma. | LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
Li ZQ, Liao WJ, Sun BL, Luo ZW, Zhong NS, Wu JB, Liu ZL, Liu JM., Free PMC Article | 10/8/2022 |
| Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma. | Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.
M Serag El-Dien M, Fathy Mahmoud S, Alhanafy AM, Mohamed Zanaty F, Shawky Holah N. | 05/21/2022 |
| Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling. | Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.
Dong M, Xiao Q, Hu J, Cheng F, Zhang P, Zong W, Tang Q, Li X, Mao F, He Y, Yu X, Wan F, Lei T, Guo D, Wang B. | 12/25/2021 |
| LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes. | LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.
Herdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C, Arner P, Henriksson R, Franks PW, Hedman H., Free PMC Article | 06/26/2021 |
| A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus. | A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus.
Hall A, Moore AK, Hernandez DG, Billingsley KJ, Bubb VJ, Quinn JP, Nabec North American Brain Expression Consortium., Free PMC Article | 03/6/2021 |
| epidermal LRIG2 excess is associated with activated EGFR/ERBB4-MAPK signaling and accelerated tumor progression. | The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis.
Hoesl C, Fröhlich T, Hundt JE, Kneitz H, Goebeler M, Wolf R, Schneider MR, Dahlhoff M., Free PMC Article | 06/20/2020 |
| Study discovered novel homozygous missense LRIG2 variants that were predicted to be pathogenic in 2 individuals with non-syndromic bladder outlet obstruction. These observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and heparanase 2 for nerve patterning in the urinary tract. | Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Roberts NA, Hilton EN, Lopes FM, Singh S, Randles MJ, Gardiner NJ, Chopra K, Coletta R, Bajwa Z, Hall RJ, Yue WW, Schaefer F, Weber S, Henriksson R, Stuart HM, Hedman H, Newman WG, Woolf AS., Free PMC Article | 04/4/2020 |
| LRIG2 was identified as the downstream target of miR-149-5p and its expression was regulated by LINC00461/miR-149-5p axis. | Long non-coding RNA LINC00461/miR-149-5p/LRIG2 axis regulates hepatocellular carcinoma progression.
Ji D, Wang Y, Li H, Sun B, Luo X. | 02/8/2020 |
| Study demonstrated that LRIG2 promoted the PDGFRBinduced proliferation of glioblastoma multiforme cells in vitro and in vivo through regulating the PDGFRB signalingmediated cell cycle progression. | LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling.
Xiao Q, Dong M, Cheng F, Mao F, Zong W, Wu K, Wang H, Xie R, Wang B, Lei T, Guo D., Free PMC Article | 12/1/2018 |
| Role of LRIG2 in cancer [review] | LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.
Malik U, Javed A. | 10/14/2017 |
| LRIG2 gene is overexpressed in invasive pituitary adenoma. | Association of expression of Leucine-rich repeats and immunoglobulin-like domains 2 gene with invasiveness of pituitary adenoma.
Zhang H, Yan Q, Xu S, Ou Y, Ye F, Wang B, Lei T, Guo D. | 09/13/2014 |
| A subset of urofacial syndrome-affected individuals have biallelic mutations in LRIG2 | LRIG2 mutations cause urofacial syndrome.
Stuart HM, Roberts NA, Burgu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson JE, Mermerkaya M, Silay MS, Lewis MA, Olondriz MB, Gener B, Beetz C, Varga RE, Gülpınar O, Süer E, Soygür T, Ozçakar ZB, Yalçınkaya F, Kavaz A, Bulum B, Gücük A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG., Free PMC Article | 04/6/2013 |
| Cytoplasmic expression of LRIG2 is associated with meningiomas. | Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression.
Ghasimi S, Haapasalo H, Eray M, Korhonen K, Brännström T, Hedman H, Andersson U. | 10/20/2012 |
| LRIG1 and LRIG2 expressions were seen in precancerous cervical epithelium and found to increase with increasing grade. | Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.
Lindström AK, Asplund A, Hellberg D. | 09/24/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.
Andersson U, Schwartzbaum J, Wiklund F, Sjöström S, Liu Y, Tsavachidis S, Ahlbom A, Auvinen A, Collatz-Laier H, Feychting M, Johansen C, Kiuru A, Lönn S, Schoemaker MJ, Swerdlow AJ, Henriksson R, Bondy M, Melin B. | 06/30/2010 |
| This is the first report of an LRIG protein showing a negative effect on survival, suggesting that LRIG2 might have a function different from that of LRIG1, and possibly contributing to the etiology of oligodendroglioma. | Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.
Holmlund C, Haapasalo H, Yi W, Raheem O, Brännström T, Bragge H, Henriksson R, Hedman H. | 01/21/2010 |
| LRIG proteins may have a role in epidermal homeostasis and psoriasis | Redistribution of LRIG proteins in psoriasis.
Karlsson T, Mark EB, Henriksson R, Hedman H. | 01/21/2010 |
| LRIG2 was found to be a glycoprotein with an molecular weight of 132 kDa, which was encoded by a gene on human chromosome 1p13 and its mRNA was present in all tissues analyzed. | Characterization and tissue-specific expression of human LRIG2.
Holmlund C, Nilsson J, Guo D, Starefeldt A, Golovleva I, Henriksson R, Hedman H. | 01/21/2010 |