| A novel tRNA-derived fragment tRF-3023b suppresses inflammation in RAW264.7 cells by targeting Cul4a through NF-kappaB signaling. | A novel tRNA-derived fragment tRF-3023b suppresses inflammation in RAW264.7 cells by targeting Cul4a through NF-κB signaling.
Zhang Y, Zhou H, Chen X, Wang N, Zhan Y, Huang Z, Ruan K, Qi Q, Deng M, Jiang Y. | 02/15/2024 |
| S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. | S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
Hu Y, Zhang R, Lu S, Zhang W, Wang D, Ge Y, Jiang F, Qin X, Liu Y., Free PMC Article | 05/15/2023 |
| Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis. | Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis.
Yin Y, Zhu L, Li Q, Zhou P, Ma L., Free PMC Article | 12/4/2021 |
| REVIEW: versatile roles of the CRL4 E3 ligase complexes in tumorigenesis dependent on the evidence obtained from knockout and transgenic mouse models as well as biochemical and pathological studies | Cullin 4-DCAF Proteins in Tumorigenesis.
Zhou Z, Song X, Wavelet CM, Wan Y. | 02/29/2020 |
| These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation. | The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.
Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I., Free PMC Article | 10/22/2016 |
| CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition. | CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.
Pan Y, Wang B, Yang X, Bai F, Xu Q, Li X, Gao L, Ma C, Liang X., Free PMC Article | 09/24/2016 |
| Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells. | Lung tumourigenesis in a conditional Cul4A transgenic mouse model.
Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L., Free PMC Article | 07/12/2014 |
| this study revealed an indispensable role for Cul4a during male germ cell meiosis. | The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.
Yin Y, Lin C, Kim ST, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L., Free PMC Article | 09/10/2011 |
| The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B gene is silenced due to meiotic sex chromosome inactivation. | Cul4A is essential for spermatogenesis and male fertility.
Kopanja D, Roy N, Stoyanova T, Hess RA, Bagchi S, Raychaudhuri P., Free PMC Article | 05/28/2011 |
| Cul4A is required for efficient cell proliferation, control of centrosome amplification and genome stability. | Proliferation defects and genome instability in cells lacking Cul4A.
Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, Raychaudhuri P., Free PMC Article | 01/21/2010 |
| Data show that CUL4A restricts cellular repair capacity by regulating nucleotide excision repair and the G1/S checkpoint through selective degradation of the DDB2 and XPC DNA damage sensors and the p21/CIP1/WAF1 checkpoint effector. | CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, Zhou P., Free PMC Article | 01/21/2010 |
| Data show that CUL4A was a novel Wnt target gene in both mouse and human cells and that CUL4A physically interacted with p27(KIP1) in Wnt-responding cells. | A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF., Free PMC Article | 01/21/2010 |
| Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure | Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis.
Waning DL, Li B, Jia N, Naaldijk Y, Goebel WS, HogenEsch H, Chun KT., Free PMC Article | 01/21/2010 |
| Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity | Cul4A is required for hematopoietic stem-cell engraftment and self-renewal.
Li B, Jia N, Waning DL, Yang FC, Haneline LS, Chun KT., Free PMC Article | 01/21/2010 |
| a Cul4A ubiquitin ligase positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 to accumulate and signal cell cycle exit | Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis.
Li B, Jia N, Kapur R, Chun KT., Free PMC Article | 01/21/2010 |
| CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc. | CUL-4A is critical for early embryonic development.
Li B, Ruiz JC, Chun KT., Free PMC Article | 01/21/2010 |
| Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation. | Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle.
Li B, Yang FC, Clapp DW, Chun KT. | 01/21/2010 |