| The prognostic value and immunological role of MVP in pan-cancer study. | The prognostic value and immunological role of MVP in pan-cancer study.
Li C, Gao M, Zha N, Guo G., Free PMC Article | 10/11/2024 |
| Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6. | Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S., Free PMC Article | 02/29/2024 |
| Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. | Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.
Wang W, Yan T, Guo W, Niu J, Zhao Z, Sun K, Zhang H, Yu Y, Ren T., Free PMC Article | 03/5/2022 |
| MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. | MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.
Pietras P, Leśniczak-Staszak M, Kasprzak A, Andrzejewska M, Jopek K, Sowiński M, Rucinski M, Lyons SM, Ivanov P, Szaflarski W., Free PMC Article | 12/18/2021 |
| Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. | Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.
Ramberg H, Richardsen E, de Souza GA, Rakaee M, Stensland ME, Braadland PR, Nygård S, Ögren O, Guldvik IJ, Berge V, Svindland A, Taskén KA, Andersen S., Free PMC Article | 10/2/2021 |
| Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP). | Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).
Lou L, Wang J, Lv F, Wang G, Li Y, Xing L, Shen H, Zhang X. | 09/25/2021 |
| This is the first report showing that high bone marrow LRP expression predicts significant favorable therapeutic outcome. Peripheral blood LRP expression as well as marrow and blood MDR1 and MRP2 expression have no predictive value in AML patients treated with standard dose cytarabine and daunorubicin 3+7 regimen. | Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.
Kulsoom B, Shamsi TS, Afsar NA., Free PMC Article | 06/27/2020 |
| This study provides evidence that Notch1 activates AKT pathway and promotes EMT partly through direct activation of MVP. | Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.
Xiao YS, Zeng D, Liang YK, Wu Y, Li MF, Qi YZ, Wei XL, Huang WH, Chen M, Zhang GJ. | 10/12/2019 |
| Study found that MVP expression was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues. Higher MVP expression was correlated with better clinical outcomes in patients with lung cancer. Further findings demonstrate that MVP may act as a lung tumor suppressor via inhibiting STAT3 pathway. | Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway.
Bai H, Wang C, Qi Y, Xu J, Li N, Chen L, Jiang B, Zhu X, Zhang H, Li X, Yang Q, Ma J, Xu Y, Ben J, Chen Q., Free PMC Article | 09/7/2019 |
| Study shows that adipocytes induce major vault protein (MVP)-related multidrug-resistant phenotype in breast cancer cells, which could contribute to obesity-related chemoresistance. In a series of human breast tumors, a gradient of MVP expression was observed, and it was higher at the invasive front, where tumor cells are at close proximity to adipocytes, highlighting the clinical relevance of these results. | Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP).
Lehuédé C, Li X, Dauvillier S, Vaysse C, Franchet C, Clement E, Esteve D, Longué M, Chaltiel L, Le Gonidec S, Lazar I, Geneste A, Dumontet C, Valet P, Nieto L, Fallone F, Muller C., Free PMC Article | 07/27/2019 |
| Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Up-regulation of MVP expression in macrophages of visceral adipose tissues was correlated with obesity in both humans and mice, suggesting that MVP be involved in obesity-associated inflammation.Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases. | Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, Tong X, Chen L, Liu X, Zhang Y, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Xu Y, Chen Q., Free PMC Article | 05/25/2019 |
| B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhancing B-RAF and MEK interaction. B7-H3 expression increases stem cell population by binding to MVP which regulates the activation of the MAPK kinase pathway. Depletion of MVP blocks the activation of MEK induced by B7-H3 and dramatically inhibits B7-H3 induced stem cells. | Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation.
Liu Z, Zhang W, Phillips JB, Arora R, McClellan S, Li J, Kim JH, Sobol RW, Tan M., Free PMC Article | 03/16/2019 |
| KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. | Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth.
Vuorinen EM, Rajala NK, Rauhala HE, Nurminen AT, Hytönen VP, Kallioniemi A. | 12/22/2018 |
| Knockout of MVP leads to miR-193a accumulation in the exosomal donor cells instead of exosomes, inhibiting tumour progression. | MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.
Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG., Free PMC Article | 11/10/2018 |
| The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant. | Expression of resistance gene and prognosis of chemotherapy in primary epithelial ovarian cancer.
Yang F, Gao B, Chen W, Du E, Liang Y, Hu X, Yang X., Free PMC Article | 10/27/2018 |
| KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane | Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Pan LN, Zhang Y, Zhu CJ, Dong ZX., Free PMC Article | 08/11/2018 |
| Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity | vPARP Adjusts MVP Expression in Drug-resistant Cell Lines in Conjunction with MDR Proteins.
Wojtowicz K, Januchowski R, Nowicki M, Zabel M. | 08/19/2017 |
| involved in doxorubicin resistance of non-small cell lung cancer | Mechanisms underlying lung resistance-related protein (LRP)-mediated doxorubicin resistance of non-small cell lung cancer cells.
Chen YL, Yang TY, Wu CL, Chen KC, Hsu SL, Hsueh CM. | 06/24/2017 |
| Study found significant upregulation of MVP and BCRP whereas MRP1 and UGT1A4 were unaltered in drug resistant epilepsy brains. While upregulation of BCRP was significantly higher in mesial temporal lobe epilepsy (9.34+/-0.45; p<0.05), upregulation of MVP was significantly higher in focal cortical dysplasia (2.94+/-0.65; p<0.01). | Upregulation of breast cancer resistance protein and major vault protein in drug resistant epilepsy.
Banerjee Dixit A, Sharma D, Srivastava A, Banerjee J, Tripathi M, Prakash D, Sarat Chandra P. | 04/22/2017 |
| Taxus chinensis var.-mediated downregulation of MRP1, MDR1, and LRP might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells. | Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB. | 02/25/2017 |
| We believe that for the first time, genetic variants at XRCC6 and MVP genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer | Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.
Henríquez-Hernández LA, Valenciano A, Foro-Arnalot P, Álvarez-Cubero MJ, Cozar JM, Suárez-Novo JF, Castells-Esteve M, Fernández-Gonzalo P, De-Paula-Carranza B, Ferrer M, Guedea F, Sancho-Pardo G, Craven-Bartle J, Ortiz-Gordillo MJ, Cabrera-Roldán P, Rodríguez-Melcón JI, Herrera-Ramos E, Rodríguez-Gallego C, Lara PC. | 10/29/2016 |
| MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population. | Absence of association between major vault protein (MVP) gene polymorphisms and drug resistance in Chinese Han patients with partial epilepsy.
Zhou L, Zhang M, Long H, Long L, Xie Y, Liu Z, Kang J, Chen Q, Feng L, Xiao B. | 09/17/2016 |
| NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily. | Concomitance of P-gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non-Small Cell Lung Cancers.
Wei H, Lu W, Li M, Zhang Q, Lu S., Free PMC Article | 07/16/2016 |
| The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma. | Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.
Navarro L, Gil-Benso R, Megías J, Muñoz-Hidalgo L, San-Miguel T, Callaghan RC, González-Darder JM, López-Ginés C, Cerdá-Nicolás MJ. | 01/30/2016 |
| Bag3-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer | Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA., Free PMC Article | 09/5/2015 |