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    FGFBP1 fibroblast growth factor binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 9982, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes.

    HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes.
    Lu DD, Huang N, Li SA, Fang JR, Lai CH, Wang JK, Chan KS, Johnson MD, Lin CY.

    06/28/2023
    Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.

    Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.
    Chen X, Miao M, Zhou M, Chen J, Li D, Zhang L, Sun A, Guan M, Wang Z, Liu P, Zhang S, Zha X, Fan X., Free PMC Article

    01/29/2022
    The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma.

    The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma.
    Zhang W, Zhou Y, Li C, Xu S, Li M, Liu W, Ma Y, Wang H., Free PMC Article

    08/28/2021
    FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.

    FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
    Zhang Z, Qin Y, Ji S, Xu W, Liu M, Hu Q, Ye Z, Fan G, Yu X, Liu W, Xu X.

    08/7/2021
    These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells.

    Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells.
    Zhu HY, Bai WD, Liu JQ, Zheng Z, Guan H, Zhou Q, Su LL, Xie ST, Wang YC, Li J, Li N, Zhang YJ, Wang HT, Hu DH., Free PMC Article

    01/20/2018
    Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension.

    Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
    Tassi E, Lai EY, Li L, Solis G, Chen Y, Kietzman WE, Ray PE, Riegel AT, Welch WJ, Wilcox CS, Wellstein A., Free PMC Article

    12/23/2017
    Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression.

    Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.
    Huang W, Chen Z, Shang X, Tian D, Wang D, Wu K, Fan D, Xia L.

    08/8/2015
    overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.

    A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.
    Yang Z, Yang Z, Zou Q, Yuan Y, Li J, Li D, Liang L, Zeng G, Chen S.

    12/20/2014
    FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations.

    Pathway analysis shows association between FGFBP1 and hypertension.
    Tomaszewski M, Charchar FJ, Nelson CP, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, van der Harst P, Wang WY, Maric C, Zukowska-Szczechowska E, Samani NJ., Free PMC Article

    07/2/2011
    Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk.

    A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.
    Hoppman N, McLenithan JC, McBride DJ, Shen H, Bruder J, Bauer RL, Shaffer JR, Liu J, Streeten EA, Shuldiner AR, Kammerer CM, Mitchell BD, Hoppman N, McLenithan JC, McBride DJ, Shen H, Bruder J, Bauer RL, Shaffer JR, Liu J, Streeten EA, Shuldiner AR, Kammerer CM, Mitchell BD., Free PMC Articles: PMC2902654, PMC2902654

    10/23/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (3) articles

    An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K.

    Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC.

    A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.
    Hoppman N, McLenithan JC, McBride DJ, Shen H, Bruder J, Bauer RL, Shaffer JR, Liu J, Streeten EA, Shuldiner AR, Kammerer CM, Mitchell BD, Hoppman N, McLenithan JC, McBride DJ, Shen H, Bruder J, Bauer RL, Shaffer JR, Liu J, Streeten EA, Shuldiner AR, Kammerer CM, Mitchell BD.

    06/30/2010
    KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription.

    Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
    Zheng HQ, Zhou Z, Huang J, Chaudhury L, Dong JT, Chen C.

    01/21/2010
    KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.

    KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
    Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C., Free PMC Article

    01/21/2010
    Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair.

    The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
    Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S.

    01/21/2010
    The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.

    Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.
    Ray PE, Tassi E, Liu XH, Wellstein A.

    01/21/2010
    the FGF interaction domain is contained in the C terminus of FGF-BP1

    Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.
    Xie B, Tassi E, Swift MR, McDonnell K, Bowden ET, Wang S, Ueda Y, Tomita Y, Riegel AT, Wellstein A.

    01/21/2010
    FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review]

    The fibroblast growth factor-binding protein FGF-BP.
    Abuharbeid S, Czubayko F, Aigner A.

    01/21/2010
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