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    TRPC5 transient receptor potential cation channel subfamily C member 5 [ Homo sapiens (human) ]

    Gene ID: 7224, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRPC5provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 5provided by HGNC
    Primary source
    HGNC:HGNC:12337
    See related
    Ensembl:ENSG00000072315 MIM:300334; AllianceGenome:HGNC:12337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRP5; PPP1R159
    Summary
    This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See TRPC5 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (111768011..112082776, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (110216352..110531119, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (111011239..111326004, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110924066-110924785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29860 Neighboring gene RNA, 5S ribosomal pseudogene 512 Neighboring gene ALG13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20944 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:111155775-111156274 Neighboring gene TRPC5 opposite strand Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29861 Neighboring gene retrotransposon Gag like 4 Neighboring gene divergent-paired related homeobox pseudogene 7 Neighboring gene CCDC121 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of TRPC5 channels by intracellular ATP. Dattilo M, et al. Mol Pharmacol, 2008 Jan. PMID 17925457
    2. Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Ma X, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988121, Free PMC Article
    3. Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+ release and ion channel trafficking. Hong C, et al. Biochem Biophys Res Commun, 2012 Apr 27. PMID 22490661
    4. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Jemal I, et al. Pflugers Arch, 2014 Aug. PMID 24177920
    5. Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Ma X, et al. Proc Natl Acad Sci U S A, 2014 Apr 29. PMID 24733904, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca[2+] and NO signals.
      Title: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca(2+) and NO signals.
    2. Thermosensing ability of TRPC5: current knowledge and unsettled questions.
      Title: Thermosensing ability of TRPC5: current knowledge and unsettled questions.
    3. MiR-138-5p Inhibits Thyroid Cancer Cell Growth and Stemness by Targeting TRPC5/Wnt/beta-Catenin Pathway.
      Title: MiR-138-5p Inhibits Thyroid Cancer Cell Growth and Stemness by Targeting TRPC5/Wnt/β-Catenin Pathway.
    4. Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
      Title: Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
    5. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
      Title: Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
    6. Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
      Title: Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
    7. Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
      Title: Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
    8. TRPC5 in cardiovascular diseases.
      Title: TRPC5 in cardiovascular diseases.
    9. Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCbeta and PIP2 in vasopressin-mediated excitation of medial central amygdala neurons.
      Title: Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCβ and PIP(2) in vasopressin-mediated excitation of medial central amygdala neurons.
    10. PIP2 regulation of TRPC5 channel activation and desensitization.
      Title: PIP(2) regulation of TRPC5 channel activation and desensitization.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide and candidate gene association study of cigarette smoking behaviors.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actinin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium channel activity TAS
    Traceable Author Statement
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short transient receptor potential channel 5
    Names
    TRP-5
    hTRP5
    protein phosphatase 1, regulatory subunit 159
    transient receptor potential channel 5
    transient receptor protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021215.2 RefSeqGene

      Range
      5001..313463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_012471.3 → NP_036603.1  short transient receptor potential channel 5

      See identical proteins and their annotated locations for NP_036603.1

      Status: REVIEWED

      Source sequence(s)
      AF054568, AL031388, AL049563
      Consensus CDS
      CCDS14561.1
      UniProtKB/Swiss-Prot
      B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514
      Related
      ENSP00000262839.2, ENST00000262839.3
      Conserved Domains (2) summary
      TIGR00870
      Location:17 → 756
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:35 → 67
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      111768011..112082776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029774.2 → XP_016885263.1  short transient receptor potential channel 5 isoform X1

      UniProtKB/Swiss-Prot
      B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514
      Conserved Domains (2) summary
      TIGR00870
      Location:17 → 756
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:35 → 67
      ANK; ANK repeat [structural motif]

    2. XM_047442413.1 → XP_047298369.1  short transient receptor potential channel 5 isoform X2

      UniProtKB/TrEMBL
      Q59G51

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      110216352..110531119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327673.1 → XP_054183648.1  short transient receptor potential channel 5 isoform X1

      UniProtKB/Swiss-Prot
      B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514

    2. XM_054327674.1 → XP_054183649.1  short transient receptor potential channel 5 isoform X2

      UniProtKB/TrEMBL
      Q59G51
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UL62.1 GenPept UniProtKB/Swiss-Prot:Q9UL62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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