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Envelope surface glycoprotein gp120
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env
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HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation |
PubMed
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env
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HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which activates NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38) |
PubMed
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env
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HIV-1 gp120-induced release of IL-6 is regulated by p38 MAPK, IkappaBalpha, and p65 NF-kappaB activation in primary human monocyte-derived dendritic cells |
PubMed
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env
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HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells |
PubMed
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env
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HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes |
PubMed
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env
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HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 |
PubMed
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env
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HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells |
PubMed
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env
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HIV-1 gp120-mediated enhancement of potassium voltage-gated channel KV1.3 protein is required for microglia neurotoxicity through the p38 MAPK signaling pathway |
PubMed
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env
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p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) |
PubMed
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env
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Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves p38 MAPK signaling pathway |
PubMed
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env
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HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway |
PubMed
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env
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Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia |
PubMed
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env
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HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1 |
PubMed
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env
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Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) |
PubMed
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env
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Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB |
PubMed
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env
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HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity |
PubMed
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env
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The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 |
PubMed
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env
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CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK |
PubMed
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env
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HIV-1 gp120-induced increases in caspase-3 activity, neurite losses and neuronal death are prevented by p38 MAPK, but not c-jun-N-terminal kinase |
PubMed
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env
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STAT1 associates with p38 MAP kinase in a time-dependent manner after HIV-1 gp120/HCV E2 costimulation in human hepatocytes |
PubMed
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env
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HCV-E2 and HIV-1 gp120 act collaboratively to trigger a specific set of downstream signaling pathways that include activation of p38 mitogen-activated protein (MAP) kinase and the tyrosine phosphatase, SHP2, in hepatocytes |
PubMed
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env
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CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not |
PubMed
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env
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Morphine potentiates HIV-1 gp120-induced neuronal apoptosis, which involves activation of the p38 MAPK cellular signaling pathway |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells |
PubMed
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Envelope transmembrane glycoprotein gp41
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env
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HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells |
PubMed
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env
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p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) |
PubMed
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Nef
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nef
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HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 |
PubMed
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nef
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HIV-1 Nef induces phosphorylation of p38 MAPK in M2-type macrophages |
PubMed
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nef
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Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5 |
PubMed
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nef
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HIV-1 Nef-induced programmed death 1 (PD-1) upregulation requires its proline-rich motif and the activation of the downstream kinase p38 |
PubMed
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nef
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Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter |
PubMed
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nef
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HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members |
PubMed
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Tat
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tat
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HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes |
PubMed
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tat
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Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 |
PubMed
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tat
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HIV-1 Tat induces phosphorylation of MAPK14 (p38) in CRT-MG human astroglioma cells |
PubMed
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tat
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HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes |
PubMed
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tat
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HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes |
PubMed
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tat
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HIV-1 Tat-mediated upregulation of ICAM-1 expression involves MEK1/2, JNK, and p38 MAPK proteins and downstream IKK2/NF-kappaB signaling pathways |
PubMed
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tat
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Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING |
PubMed
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tat
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Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 |
PubMed
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tat
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Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors |
PubMed
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tat
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Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes |
PubMed
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tat
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Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat |
PubMed
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tat
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HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha |
PubMed
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tat
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The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production |
PubMed
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tat
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Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression |
PubMed
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tat
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HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) |
PubMed
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Vpr
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vpr
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HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr |
PubMed
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vpr
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HIV-1 Vpr induces IL-6 production via activation of MAPK p38 |
PubMed
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