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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001109.5 → NP_001100.3 disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor
See identical proteins and their annotated locations for NP_001100.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AK312834, AL592071, BQ007791, DA936506, DC408787
- Consensus CDS
-
CCDS31319.2
- UniProtKB/Swiss-Prot
- B4DVM6, H0YL36, H0YLR0, H0YN39, P78325
- UniProtKB/TrEMBL
-
Q14C66
- Related
- ENSP00000453302.1, ENST00000445355.8
- Conserved Domains (5) summary
-
- smart00050
Location:417 → 491
- DISIN; Homologues of snake disintegrins
- smart00608
Location:494 → 605
- ACR; ADAM Cysteine-Rich Domain
- cd04269
Location:200 → 398
- ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
- pfam01421
Location:200 → 400
- Reprolysin; Reprolysin (M12B) family zinc metalloprotease
- pfam01562
Location:43 → 154
- Pep_M12B_propep; Reprolysin family propeptide
-
NM_001164489.2 → NP_001157961.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site, which causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
- Source sequence(s)
-
AL592071, BC064500, BQ007791, DA936506, DC401057, DC408787
- Consensus CDS
-
CCDS58103.1
- UniProtKB/Swiss-Prot
-
P78325
- Related
- ENSP00000453855.1, ENST00000415217.7
- Conserved Domains (5) summary
-
- smart00050
Location:417 → 491
- DISIN; Homologues of snake disintegrins
- smart00608
Location:494 → 605
- ACR; ADAM Cysteine-Rich Domain
- cd04269
Location:200 → 398
- ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
- pfam01421
Location:200 → 400
- Reprolysin; Reprolysin (M12B) family zinc metalloprotease
- pfam01562
Location:43 → 154
- Pep_M12B_propep; Reprolysin family propeptide
-
NM_001164490.2 → NP_001157962.1 disintegrin and metalloproteinase domain-containing protein 8 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks three alternate exons and uses an alternate splice site in the coding region, which results in a frameshifted segment, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter than isoform 1.
- Source sequence(s)
-
AK301147, AL592071, BI908229, BQ007791, DA936506, DC408787
- Consensus CDS
-
CCDS58102.1
- UniProtKB/TrEMBL
-
Q14C66
- Related
- ENSP00000453043.1, ENST00000485491.6
- Conserved Domains (4) summary
-
- smart00050
Location:378 → 452
- DISIN; Homologues of snake disintegrins
- smart00608
Location:455 → 562
- ACR; ADAM Cysteine-Rich Domain
- cd04269
Location:161 → 359
- ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
- pfam01421
Location:161 → 361
- Reprolysin; Reprolysin (M12B) family zinc metalloprotease