CORO1A coronin 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO1Aprovided by HGNC
Official Full Name: coronin 1Aprovided by HGNC
Primary source: HGNC:HGNC:2252
See related: Ensembl:ENSG00000102879 MIM:605000; AllianceGenome:HGNC:2252
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Expression: Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (30183602..30189076)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (30468184..30473658)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (30194923..30200397)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.
Title: Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.
Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.
Title: Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.
Coro1A has a role in platelet biology with impact on spreading, aggregation and thrombosis
Title: The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation.
Title: HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.
Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW]
Title: Emergent Role of Coronin-1a in Neuronal Signaling.
It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism.
Title: Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.
Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens.
Title: Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation.
Title: Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation.
Title: Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres
Title: Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Severe combined immunodeficiency due to CORO1A deficiency MedGen: C3809383 OMIM: 615401 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:486443

RH47208 (e-PCR)
- UniSTS:88686

NoName (e-PCR)
- UniSTS:494834

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin monomer binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables myosin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
NOT involved_in immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in leukocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in thymocyte migration	IEA Inferred from Electronic Annotation more info
involved_in uropod organization	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
colocalizes_with cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-1A

Names: clipin-A; coronin, actin binding protein, 1A; coronin-1; coronin-like protein A; coronin-like protein p57; tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023415.1 RefSeqGene

Range

4806..10472

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_195

mRNA and Protein(s)

NM_001193333.3 → NP_001180262.1 coronin-1A

See identical proteins and their annotated locations for NP_001180262.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK314714, BC110374, DA256300, U34690

Consensus CDS

CCDS10673.1

UniProtKB/Swiss-Prot

B2RBL1, P31146, Q2YD73

UniProtKB/TrEMBL

H3BRY3

Related

ENSP00000455552.1, ENST00000570045.5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_007074.4 → NP_009005.1 coronin-1A

See identical proteins and their annotated locations for NP_009005.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC110374, U34690

Consensus CDS

CCDS10673.1

UniProtKB/Swiss-Prot

B2RBL1, P31146, Q2YD73

UniProtKB/TrEMBL

H3BRY3

Related

ENSP00000219150.6, ENST00000219150.10

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...