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    PRG2 proteoglycan 2, pro eosinophil major basic protein [ Homo sapiens (human) ]

    Gene ID: 5553, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRG2provided by HGNC
    Official Full Name
    proteoglycan 2, pro eosinophil major basic proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9362
    See related
    Ensembl:ENSG00000186652 MIM:605601; AllianceGenome:HGNC:9362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MBP; BMPG; MBP1; proMBP
    Summary
    The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
    Annotation information
    Note: MBP is an alias on both PRG2 (Gene ID: 5553, "major basic protein") and MBL2 (Gene ID: 4153, "mannose-binding protein C"). MBP is also the official symbol on GeneID: 4155 (myelin basic protein). [01 Jun 2018]
    Expression
    Restricted expression toward placenta (RPKM 1164.9) See more
    Orthologs
    NEW
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    Genomic context

    See PRG2 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57386780..57390650, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57336805..57340674, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57154253..57158123, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4716 Neighboring gene purinergic receptor P2X 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:57146812-57148011 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57182050-57182550 Neighboring gene solute carrier family 43 member 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57193011-57194210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3346 Neighboring gene RNA, 5S ribosomal pseudogene 341

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC14537

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bone marrow proteoglycan
    Names
    eosinophil granule major basic protein
    eosinophil major basic protein
    natural killer cell activator
    proteoglycan 2 preproprotein
    proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243245.3NP_001230174.1  bone marrow proteoglycan isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001230174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1.
      Source sequence(s)
      AP000781
      Consensus CDS
      CCDS58133.1
      UniProtKB/Swiss-Prot
      P13727
      Related
      ENSP00000433231.1, ENST00000533605.5
      Conserved Domains (1) summary
      cd03598
      Location:101211
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
    2. NM_001302926.2NP_001289855.1  bone marrow proteoglycan isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001289855.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AP000781
      Consensus CDS
      CCDS7955.1
      UniProtKB/Swiss-Prot
      A6XMW0, B2R5I1, P13727, P81448, Q14227, Q6ICT2
      Conserved Domains (1) summary
      cd03598
      Location:106222
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
    3. NM_001302927.2NP_001289856.1  bone marrow proteoglycan isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001289856.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AP000781
      Consensus CDS
      CCDS7955.1
      UniProtKB/Swiss-Prot
      A6XMW0, B2R5I1, P13727, P81448, Q14227, Q6ICT2
      Related
      ENSP00000433016.1, ENST00000525955.1
      Conserved Domains (1) summary
      cd03598
      Location:106222
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
    4. NM_002728.6NP_002719.3  bone marrow proteoglycan isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_002719.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AP000781
      Consensus CDS
      CCDS7955.1
      UniProtKB/Swiss-Prot
      A6XMW0, B2R5I1, P13727, P81448, Q14227, Q6ICT2
      Related
      ENSP00000312134.5, ENST00000311862.10
      Conserved Domains (1) summary
      cd03598
      Location:106222
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57386780..57390650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57336805..57340674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)