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    EIF5A2 eukaryotic translation initiation factor 5A2 [ Homo sapiens (human) ]

    Gene ID: 56648, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF5A2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 5A2provided by HGNC
    Primary source
    HGNC:HGNC:3301
    See related
    Ensembl:ENSG00000163577 MIM:605782; AllianceGenome:HGNC:3301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF-5A2; eIF5AII
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 2.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF5A2 in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (170888418..170908637, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (173672753..173692976, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170606207..170626426, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNY5 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170587696-170588422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170588423-170589148 Neighboring gene ribosomal protein L22 like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170601523-170602103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14888 Neighboring gene KLF7 pseudogene 1 Neighboring gene RNA, U1 small nuclear 70, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. Yang GF, et al. Gynecol Oncol, 2009 Feb. PMID 19054548
    2. Knockdown of eukaryotic translation initiation factor 5A2 enhances the therapeutic efficiency of doxorubicin in hepatocellular carcinoma cells by triggering lethal autophagy. Tang Y, et al. Int J Oncol, 2020 Dec. PMID 33174013, Free PMC Article
    3. EIF5A2 is a novel chemoresistance gene in breast cancer. Liu Y, et al. Breast Cancer, 2015 Nov. PMID 24638963
    4. EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis. Wang K, et al. Stem Cell Res Ther, 2021 Mar 16. PMID 33726845, Free PMC Article
    5. Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion. Khosravi S, et al. Br J Cancer, 2014 Jan 21. PMID 24178756, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma.
      Title: MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma.
    2. Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression.
      Title: Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression.
    3. microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
      Title: microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
    4. EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer Cells through the TGF-beta Signaling Pathway.
      Title: EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer Cells through the TGF-β Signaling Pathway.
    5. MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta signaling pathway.
      Title: MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-β signaling pathway.
    6. EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells.
      Title: EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells.
    7. EIF5A2 promotes proliferation and invasion of intrahepatic cholangiocarcinoma cells.
      Title: EIF5A2 promotes proliferation and invasion of intrahepatic cholangiocarcinoma cells.
    8. Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.
      Title: Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.
    9. HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.
      Title: HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.
    10. The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
      Title: The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-2
    Names
    eIF-5A-2
    eukaryotic initiation factor 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020390.6 → NP_065123.1  eukaryotic translation initiation factor 5A-2

      See identical proteins and their annotated locations for NP_065123.1

      Status: VALIDATED

      Source sequence(s)
      AY205261
      Consensus CDS
      CCDS3214.1
      UniProtKB/Swiss-Prot
      B2R4V5, Q9GZV4
      Related
      ENSP00000295822.2, ENST00000295822.7
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      170888418..170908637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      173672753..173692976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZV4.3 GenPept UniProtKB/Swiss-Prot:Q9GZV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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