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    LGALS14 galectin 14 [ Homo sapiens (human) ]

    Gene ID: 56891, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LGALS14provided by HGNC
    Official Full Name
    galectin 14provided by HGNC
    Primary source
    HGNC:HGNC:30054
    See related
    Ensembl:ENSG00000006659 MIM:607260; AllianceGenome:HGNC:30054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLC2; PPL13
    Summary
    This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward placenta (RPKM 25.5) See more
    Orthologs
    all
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    Genomic context

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    See LGALS14 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39704481..39709444)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42508740..42513703)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40195121..40200084)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14626 Neighboring gene ribosomal protein S29 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene Charcot-Leyden crystal galectin Neighboring gene leucine twenty homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells]. Yang XY, et al. Ai Zheng, 2006 Jul. PMID 16831268
    2. Structure-function studies of galectin-14, an important effector molecule in embryology. Si Y, et al. FEBS J, 2021 Feb. PMID 32525264
    3. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). Yang QS, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997112
    4. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Than NG, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19497882, Free PMC Article
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Shiffman D, et al. Arterioscler Thromb Vasc Biol, 2008 Jan. PMID 17975119, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-function studies of galectin-14, an important effector molecule in embryology.
      Title: Structure-function studies of galectin-14, an important effector molecule in embryology.
    2. CIC-2 siRNA could inhibit the cell proliferation of a human glioma cell line U-87.
      Title: [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells].
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
    4. cloning and expression in placenta - base sequence and amino acid sequences are given
      Title: Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC22235

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    placental protein 13-like
    Names
    Charcot-Leyden crystal protein 2
    gal-14
    lectin, galactoside-binding, soluble, 14
    placental protein 13-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020129.3 → NP_064514.1  placental protein 13-like isoform 1

      See identical proteins and their annotated locations for NP_064514.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) appears to be the major transcript. It lacks an exon compared to variant 2. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 2.
      Source sequence(s)
      AF267852
      Consensus CDS
      CCDS46073.1
      UniProtKB/Swiss-Prot
      A8MPV8, B2R530, C5HZ19, Q7Z4X8, Q8TCE9, Q96KD4, Q96KD5, Q96KD6, Q9NR03
      Related
      ENSP00000375905.2, ENST00000392052.8
      Conserved Domains (1) summary
      pfam00337
      Location:5 → 137
      Gal-bind_lectin; Galactoside-binding lectin

    2. NM_203471.2 → NP_982297.1  placental protein 13-like isoform 2

      See identical proteins and their annotated locations for NP_982297.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AI167958, BC022257, BG434228
      Consensus CDS
      CCDS12542.1
      UniProtKB/Swiss-Prot
      Q8TCE9
      Related
      ENSP00000353893.2, ENST00000360675.7
      Conserved Domains (1) summary
      pfam00337
      Location:37 → 166
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39704481..39709444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42508740..42513703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCE9.2 GenPept UniProtKB/Swiss-Prot:Q8TCE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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