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    DPP10 dipeptidyl peptidase like 10 [ Homo sapiens (human) ]

    Gene ID: 57628, updated on 27-Nov-2024

    Summary

    Official Symbol
    DPP10provided by HGNC
    Official Full Name
    dipeptidyl peptidase like 10provided by HGNC
    Primary source
    HGNC:HGNC:20823
    See related
    Ensembl:ENSG00000175497 MIM:608209; AllianceGenome:HGNC:20823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPL2; DPPY; DPRP3; DPRP-3
    Summary
    This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DPP10 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (114442641..115845780)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (114868138..116270550)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (115200218..116603356)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:115170872-115171372 Neighboring gene uncharacterized LOC124907877 Neighboring gene RNA, U2 small nuclear 41, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:115312469-115312655 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115409386-115410190 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115527347-115527874 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115578660-115579193 Neighboring gene DPP10 antisense RNA 3 Neighboring gene uncharacterized LOC105373575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115843289-115844136 Neighboring gene uncharacterized LOC105373574 Neighboring gene uncharacterized LOC107985937 Neighboring gene DPP10 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:116185039-116185693 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:116232976-116233161 Neighboring gene ribosomal protein SA pseudogene 23 Neighboring gene uncharacterized LOC105373572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:116851897-116852396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:116900117-116900937 Neighboring gene uncharacterized LOC105373576 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:117248055-117249254 Neighboring gene MT-CYB pseudogene 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive dipeptidyl peptidase 10
    Names
    DPP X
    dipeptidyl peptidase 10
    dipeptidyl peptidase IV-related protein 3
    dipeptidyl peptidase X
    dipeptidyl peptidase-like protein 2
    dipeptidyl-peptidase 10 (inactive)
    dipeptidyl-peptidase 10 (non-functional)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004360.5NP_001004360.3  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 3. The resulting isoform (short, also referred to as DPL2-s and d) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
      Consensus CDS
      CCDS33278.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000309066.8, ENST00000310323.12
      Conserved Domains (2) summary
      pfam00326
      Location:573775
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:126492
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. NM_001178034.1NP_001171505.1  inactive dipeptidyl peptidase 10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, DQ857322
      Consensus CDS
      CCDS54388.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000376855.2, ENST00000393147.6
      Conserved Domains (2) summary
      pfam00326
      Location:584786
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:137503
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    3. NM_001178036.3NP_001171507.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, as compared to variant 3. The resulting isoform (a) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000387038.1, ENST00000409163.5
      Conserved Domains (2) summary
      pfam00326
      Location:530732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    4. NM_001178037.3NP_001171508.2  inactive dipeptidyl peptidase 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 3. The resulting isoform (b) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC067947, AC093610, AC105422
      UniProtKB/TrEMBL
      Q0GLB9
      Conserved Domains (2) summary
      pfam00326
      Location:576778
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:129495
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    5. NM_001321905.3NP_001308834.2  inactive dipeptidyl peptidase 10 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      B2RCJ8
      Conserved Domains (2) summary
      pfam00326
      Location:597799
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:150516
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    6. NM_001321906.2NP_001308835.2  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
      Consensus CDS
      CCDS33278.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:573775
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:126492
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    7. NM_001321907.3NP_001308836.2  inactive dipeptidyl peptidase 10 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      B2RCJ8
      Conserved Domains (2) summary
      pfam00326
      Location:567769
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:133486
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    8. NM_001321908.3NP_001308837.2  inactive dipeptidyl peptidase 10 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:550752
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:103469
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    9. NM_001321909.3NP_001308838.2  inactive dipeptidyl peptidase 10 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:541743
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:94460
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    10. NM_001321910.3NP_001308839.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:530732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    11. NM_001321911.3NP_001308840.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:530732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    12. NM_001321912.3NP_001308841.2  inactive dipeptidyl peptidase 10 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00930
      Location:83449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:530677
      Abhydrolase; alpha/beta hydrolases
    13. NM_001321913.3NP_001308842.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Conserved Domains (2) summary
      pfam00326
      Location:326528
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:1245
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    14. NM_001321914.2NP_001308843.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
      Conserved Domains (2) summary
      pfam00326
      Location:326528
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:1245
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    15. NM_001399849.1NP_001386778.1  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC093610, AC105422
      Consensus CDS
      CCDS54389.1
    16. NM_001399850.1NP_001386779.1  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
    17. NM_001399851.1NP_001386780.1  inactive dipeptidyl peptidase 10 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
    18. NM_020868.6NP_065919.3  inactive dipeptidyl peptidase 10 isoform long

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' exon, as compared to variant 3. The resulting isoform (long, also referred to as DPL2-l) is slightly shorter and has a distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS46400.1
      UniProtKB/Swiss-Prot
      A8K1Q2, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q8N608, Q9P236
      UniProtKB/TrEMBL
      B2RCJ8
      Related
      ENSP00000386565.1, ENST00000410059.6
      Conserved Domains (2) summary
      pfam00326
      Location:580782
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:133499
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      114442641..115845780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445202.1XP_047301158.1  inactive dipeptidyl peptidase 10 isoform X1

    2. XM_047445203.1XP_047301159.1  inactive dipeptidyl peptidase 10 isoform X2

    3. XM_047445207.1XP_047301163.1  inactive dipeptidyl peptidase 10 isoform X4

    4. XM_047445205.1XP_047301161.1  inactive dipeptidyl peptidase 10 isoform X4

    5. XM_017004566.2XP_016860055.1  inactive dipeptidyl peptidase 10 isoform X3

      UniProtKB/TrEMBL
      Q0GLB7
    6. XM_047445204.1XP_047301160.1  inactive dipeptidyl peptidase 10 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      114868138..116270550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343190.1XP_054199165.1  inactive dipeptidyl peptidase 10 isoform X1

    2. XM_054343191.1XP_054199166.1  inactive dipeptidyl peptidase 10 isoform X2

    3. XM_054343193.1XP_054199168.1  inactive dipeptidyl peptidase 10 isoform X5

    4. XM_054343196.1XP_054199171.1  inactive dipeptidyl peptidase 10 isoform X4

    5. XM_054343195.1XP_054199170.1  inactive dipeptidyl peptidase 10 isoform X4

    6. XM_054343192.1XP_054199167.1  inactive dipeptidyl peptidase 10 isoform X3

    7. XM_054343194.1XP_054199169.1  inactive dipeptidyl peptidase 10 isoform X4