GPR142 G protein-coupled receptor 142 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR142provided by HGNC
Official Full Name: G protein-coupled receptor 142provided by HGNC
Primary source: HGNC:HGNC:20088
See related: Ensembl:ENSG00000257008 MIM:609046; AllianceGenome:HGNC:20088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGR2; GPRg1b
Summary: GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in stomach (RPKM 1.1), spleen (RPKM 0.3) and 9 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q25.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (74367506..74372600)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (75258167..75263271)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (72363645..72368739)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

e developed GPR142 agonists as insulin secretagogues. In this report, we show the discovery of a selective, potent small-molecule GPR142 antagonist, CLP-3094, and its pharmacological characteristics. These data support targeting this receptor for the treatment of chronic inflammatory diseases.
Title: Discovery and pharmacological effects of a novel GPR142 antagonist.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-89363 (e-PCR)
- UniSTS:170589

NoName (e-PCR)
- UniSTS:494710

GPR142_2580 (e-PCR)
- UniSTS:280709

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: probable G-protein coupled receptor 142

Names: G-protein coupled receptor 142 long form; G-protein coupled receptor PGR2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331076.1 → NP_001318005.1 probable G-protein coupled receptor 142 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AY288421, BC143807

Consensus CDS

CCDS92387.1

UniProtKB/TrEMBL

A0A1C9J7K7, J3QSD0

Related

ENSP00000464632.2, ENST00000582579.6
NM_001331077.1 → NP_001318006.1 probable G-protein coupled receptor 142 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AY288421, DY312809, DY312859

Consensus CDS

CCDS92387.1

UniProtKB/TrEMBL

A0A1C9J7K7, J3QSD0
NM_181790.1 → NP_861455.1 probable G-protein coupled receptor 142 isoform a

See identical proteins and their annotated locations for NP_861455.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AY288421

Consensus CDS

CCDS11698.1

UniProtKB/Swiss-Prot

A4CYJ8, Q7Z601, Q86SL3

Related

ENSP00000335158.4, ENST00000335666.4

Conserved Domains (1) summary

pfam00001
Location:176 → 414

7tm_1; 7 transmembrane receptor (rhodopsin family)