RTP2 receptor transporter protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RTP2provided by HGNC
Official Full Name: receptor transporter protein 2provided by HGNC
Primary source: HGNC:HGNC:32486
See related: Ensembl:ENSG00000198471 MIM:609138; AllianceGenome:HGNC:32486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Z3CXXC2
Summary: Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 3q27.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (187698259..187715691, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (190515702..190533149, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (187416047..187420345, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

further cell-surface and permeabilized immunocytochemical studies revealed that odorant receptors (ORs) and the co-expressed RTP1S proteins were retained in the Golgi when co-transfected with RTP2, indicating that RTP1S and RTP2 could play different roles in the OR trafficking process.
Title: Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables olfactory receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-transporting protein 2

Names: 3CxxC-type zinc finger protein 2; receptor (chemosensory) transporter protein 2; zinc finger, 3CxxC-type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004312.2 → NP_001004312.2 receptor-transporting protein 2

See identical proteins and their annotated locations for NP_001004312.2

Status: VALIDATED

Source sequence(s)

AC072022, AY562236, BC068081

Consensus CDS

CCDS33911.1

UniProtKB/Swiss-Prot

Q5QGT7, Q6NVH4

Related

ENSP00000350976.1, ENST00000358241.1

Conserved Domains (1) summary

pfam13695
Location:51 → 161

zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

187698259..187715691 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017006302.2 → XP_016861791.1 receptor-transporting protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5QGT7, Q6NVH4

Conserved Domains (1) summary

pfam13695
Location:51 → 161

zf-3CxxC; Zinc-binding domain
XM_017006301.2 → XP_016861790.1 receptor-transporting protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5QGT7, Q6NVH4

Conserved Domains (1) summary

pfam13695
Location:51 → 161

zf-3CxxC; Zinc-binding domain