KIF4B kinesin family member 4B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF4Bprovided by HGNC
Official Full Name: kinesin family member 4Bprovided by HGNC
Primary source: HGNC:HGNC:6322
See related: Ensembl:ENSG00000226650 MIM:609184; AllianceGenome:HGNC:6322
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q33.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (155013755..155018141)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (155547646..155552032)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (154393315..154397701)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO	PubMed
	gag	Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane	PubMed
	gag	Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: chromosome-associated kinesin KIF4B

Names: chromokinesin KIF4B; chromokinesin-B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099293.3 → NP_001092763.1 chromosome-associated kinesin KIF4B

See identical proteins and their annotated locations for NP_001092763.1

Status: REVIEWED

Source sequence(s)

AC008410, AK302388

Consensus CDS

CCDS47324.1

UniProtKB/Swiss-Prot

Q2VIQ3

UniProtKB/TrEMBL

B4DYE2

Related

ENSP00000387875.3, ENST00000435029.6

Conserved Domains (4) summary

smart00129
Location:9 → 343

KISc; Kinesin motor, catalytic domain. ATPase

COG0419
Location:406 → 995

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01372
Location:8 → 337

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam05033
Location:1072 → 1122

Pre-SET; Pre-SET motif