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    IKBIP IKBKB interacting protein [ Homo sapiens (human) ]

    Gene ID: 121457, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IKBIPprovided by HGNC
    Official Full Name
    IKBKB interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26430
    See related
    Ensembl:ENSG00000166130 MIM:609861; AllianceGenome:HGNC:26430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IKIP
    Summary
    Predicted to be involved in response to X-ray. Located in endoplasmic reticulum and nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 6.8), urinary bladder (RPKM 5.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IKBIP in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (98613404..98644788, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (98586371..98617716, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (99007182..99038566, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6845 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98987254-98987878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98987879-98988503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6847 Neighboring gene MPRA-validated peak1907 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4754 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_31387 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:99037284-99037911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:99038539-99039166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:99037912-99038538 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:99043141-99044340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:99072005-99072576 Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_31421 Neighboring gene peptidylprolyl isomerase A pseudogene 8 Neighboring gene MPRA-validated peak1909 silencer Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:99187754-99187963 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma. Hu J, et al. BMC Cancer, 2024 Jun 24. PMID 38914958, Free PMC Article
    2. IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies. Li Q, et al. Discov Med, 2023 Feb 1. PMID 37024442
    3. IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4. Li K, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jan 1. PMID 36244542
    4. hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP. Liang J, et al. Aging (Albany NY), 2021 Dec 12. PMID 34897031, Free PMC Article
    5. IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation. Wu H, et al. J Immunol, 2020 Jan 15. PMID 31826938

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma.
      Title: IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma.
    2. IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies.
      Title: IKBIP is a Predictive Biomarker Related to Immunosuppressive Microenvironment in Digestive System Malignancies.
    3. IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4.
      Title: IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4.
    4. hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP.
      Title: hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP.
    5. study identifies a previously unrecognized role for IKIP in the negative regulation of NF-kappaB activation by inhibition of IKKalpha/beta phosphorylation through the disruption of IKK complex formation
      Title: IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation.
    6. We conclude that IKIP is a novel p53 target gene with proapoptotic function.(IKIP1 protein, human)
      Title: A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IKBIP; predicted interaction to be within the endoplasmic reticulum and involved in NFKB circuitry PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31051

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to X-ray TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase-interacting protein
    Names
    I kappa B kinase interacting protein
    IKK interacting protein
    i kappa-B kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153687.4 → NP_710154.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_710154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC013283, AJ539425, BC058933, BM468651
      Consensus CDS
      CCDS9068.1
      UniProtKB/Swiss-Prot
      Q70UQ0
      Related
      ENSP00000299157.4, ENST00000299157.5
      Conserved Domains (1) summary
      cl25732
      Location:83 → 348
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_201612.4 → NP_963906.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_963906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at its 3'-terminal exon, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC013283, AJ539426
      Consensus CDS
      CCDS9067.1
      UniProtKB/Swiss-Prot
      Q6ZWH4, Q70UP9, Q70UQ0, Q86V91, Q96ND2
      Related
      ENSP00000343471.2, ENST00000342502.6
      Conserved Domains (1) summary
      cl23887
      Location:59 → 222
      DUF4349; Domain of unknown function (DUF4349)

    3. NM_201613.4 → NP_963907.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 3

      See identical proteins and their annotated locations for NP_963907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon at its 3'-terminal exon and lacks an internal exon, compared to variant 1, which results in a protein (isoform 3; also known as 3.1) with a shorter and distinct C-terminus, compared to isoform 1. The 3'-terminal exon of variant 3 contains a longer ORF which can potentially encode a protein (called isoform 3.2) that matches the C-terminus of isoform 2; however, this protein is not predicted to be translated because the ORF is overlapped by the upstream ORF encoding isoform 3.
      Source sequence(s)
      AC013283, AJ539427
      Consensus CDS
      CCDS41822.1
      UniProtKB/Swiss-Prot
      Q70UQ0
      Related
      ENSP00000376762.3, ENST00000393042.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      98613404..98644788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      98586371..98617716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70UQ0.1 GenPept UniProtKB/Swiss-Prot:Q70UQ0

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