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    MEX3D mex-3 RNA binding family member D [ Homo sapiens (human) ]

    Gene ID: 399664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEX3Dprovided by HGNC
    Official Full Name
    mex-3 RNA binding family member Dprovided by HGNC
    Primary source
    HGNC:HGNC:16734
    See related
    Ensembl:ENSG00000181588 MIM:611009; AllianceGenome:HGNC:16734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEX3; TINO; RKHD1; MEX-3D; RNF193; OK/SW-cl.4
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 6.0), fat (RPKM 4.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEX3D in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1554672..1568325, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1525487..1539144, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1554671..1568324, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985337 Neighboring gene polo like kinase 5 (inactive) Neighboring gene CRISPRi-validated cis-regulatory element chr19.367 Neighboring gene MPRA-validated peak3222 silencer Neighboring gene Sharpr-MPRA regulatory region 1835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9729 Neighboring gene RNA, 7SL, cytoplasmic 477, pseudogene Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MEX3D is an oncogenic driver in prostate cancer. Shao L, et al. Prostate, 2021 Nov. PMID 34455614, Free PMC Article
    2. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study. Sagata N, et al. Sci Rep, 2017 Oct 24. PMID 29066822, Free PMC Article
    3. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. Donnini M, et al. J Biol Chem, 2004 May 7. PMID 14769789
    4. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Buchet-Poyau K, et al. Nucleic Acids Res, 2007. PMID 17267406, Free PMC Article
    5. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. Courchet J, et al. J Biol Chem, 2008 Nov 14. PMID 18779327

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEX3D is an oncogenic driver in prostate cancer.
      Title: MEX3D is an oncogenic driver in prostate cancer.
    2. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients
      Title: Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA2031

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA destabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA localization resulting in post-transcriptional regulation of gene expression NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein MEX3D
    Names
    RING finger and KH domain-containing protein 1
    RING finger protein 193
    bcl-2 ARE RNA binding protein
    ring finger (C3HC4 type) and KH domain containing 1
    ring finger and KH domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174118.2 → NP_001167589.1  RNA-binding protein MEX3D isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005943, AF458084
      UniProtKB/Swiss-Prot
      Q86XN8
      Conserved Domains (3) summary
      smart00322
      Location:273 → 338
      KH; K homology RNA-binding domain
      cd00105
      Location:180 → 241
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:598 → 645
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_203304.4 → NP_976049.3  RNA-binding protein MEX3D isoform 1

      See identical proteins and their annotated locations for NP_976049.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC005943, AC027307
      Consensus CDS
      CCDS32865.2
      UniProtKB/Swiss-Prot
      A0PJL8, A1L023, E9PAL6, Q71M49, Q86XN8
      Related
      ENSP00000384398.3, ENST00000402693.5
      Conserved Domains (3) summary
      smart00322
      Location:273 → 338
      KH; K homology RNA-binding domain
      cd00105
      Location:180 → 241
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:598 → 645
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1554672..1568325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1525487..1539144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XN8.3 GenPept UniProtKB/Swiss-Prot:Q86XN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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