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    EPB41 erythrocyte membrane protein band 4.1 [ Homo sapiens (human) ]

    Gene ID: 2035, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EPB41provided by HGNC
    Official Full Name
    erythrocyte membrane protein band 4.1provided by HGNC
    Primary source
    HGNC:HGNC:3377
    See related
    Ensembl:ENSG00000159023 MIM:130500; AllianceGenome:HGNC:3377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HE; EL1; 4.1R
    Summary
    The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 8.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EPB41 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28887100..29120041)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28729007..28962697)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29213612..29446553)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29063168-29064066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29069801-29070309 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:29074507-29074730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29075305-29075826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29075827-29076347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29081023-29081522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29089259-29089760 Neighboring gene Sharpr-MPRA regulatory region 15715 Neighboring gene YTH N6-methyladenosine RNA binding protein F2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 606 Neighboring gene NANOG hESC enhancer GRCh37_chr1:29133560-29134067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29141619-29142120 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29161670-29162170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29162171-29162671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29181461-29181962 Neighboring gene opioid receptor delta 1 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4082 Neighboring gene GATA motif-containing MPRA enhancer 282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 608 Neighboring gene uncharacterized LOC124903886 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:29292005-29292535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29292536-29293065 Neighboring gene MPRA-validated peak137 silencer Neighboring gene Sharpr-MPRA regulatory region 9156 Neighboring gene ribosomal protein L27 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29449829-29450688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29450689-29451548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29451549-29452408 Neighboring gene transmembrane protein 200B Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29482895-29483396 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29490994-29491614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29504446-29504946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29508465-29509102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29509103-29509740 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29513125-29513770 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29513771-29514415 Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29524789-29525289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 555 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29535731-29536232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 610 Neighboring gene uncharacterized LOC124903887 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene. Parra MK, et al. EMBO J, 2008 Jan 9. PMID 18079699, Free PMC Article
    2. Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas. Huang S, et al. Eur J Clin Invest, 2001 Oct. PMID 11737230
    3. An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R. Luque CM, et al. J Biol Chem, 2003 Jan 24. PMID 12427749
    4. Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro. Krauss SW, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12960380, Free PMC Article
    5. Ubiquitination of spectrin regulates the erythrocyte spectrin-protein-4.1-actin ternary complex dissociation: implications for the sickle cell membrane skeleton. Ghatpande SS, et al. Cell Mol Biol (Noisy-le-grand), 2004 Feb. PMID 15040429

    See all (190) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical and molecular genetic analysis of a Chinese family with hereditary elliptocytosis caused by a novel mutation in the EPB41 gene.
      Title: Clinical and molecular genetic analysis of a Chinese family with hereditary elliptocytosis caused by a novel mutation in the EPB41 gene.
    2. EPB41 suppresses the Wnt/beta-catenin signaling in non-small cell lung cancer by sponging ALDOC.
      Title: EPB41 suppresses the Wnt/β-catenin signaling in non-small cell lung cancer by sponging ALDOC.
    3. Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.
      Title: Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.
    4. The c.1215G>A mutation of the EPB41 gene probably accounts for the Elliptocytosis in this family
      Title: [Identification of a Novel Mutation of EPB41 Gene in a Family Affected with Hereditary Elliptocytosis].
    5. the role of lnc-EPB41-1-1 in congenital pouch colon
      Title: Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon.
    6. 6 Single Nucleotide Polymorphisms within the EPB41 gene are significantly associated with Mandibular Prognathism (rs2762686, rs2788888, rs4654388, rs502393, rs11581096, and rs488113). The G-allele of SNP, assigned as rs4654388, showed the strongest link with an increased risk of Mandibular Prognathism in the Chinese population.
      Title: Genetic Factors Involved in Mandibular Prognathism.
    7. Using Next-Generation sequencing, we identified the causative genetic mutations in fifteen patients with clinically suspected hereditary elliptocytosis and hereditary pyropoikilocytosis and correlated the identified mutations with the clinical phenotype and ektacytometry profile.
      Title: Genotype-phenotype correlations in hereditary elliptocytosis and hereditary pyropoikilocytosis.
    8. Our study shows alternative polyadenylation to be an additional mechanism for the generation of 4.1 protein diversity in the already complex EPB41-related genes. Understanding the diversity of EPB41 RNA processing is essential for a full appreciation of the many 4.1 proteins expressed in normal and pathological tissues.
      Title: Alternative polyadenylation in a family of paralogous EPB41 genes generates protein 4.1 diversity.
    9. identification of EPB41 as a hepatocellular carcinoma susceptibility gene in vitro and in vivo; consistent with this notion, EPB41 expression is significantly decreased in HCC tissue specimens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues
      Title: Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.
    10. The 4.1R, 4.1N and 4.1B are all expressed at the lateral membrane as well as cytoplasm of epithelial cells, suggesting a potentially redundant role of these proteins.
      Title: Comprehensive characterization of protein 4.1 expression in epithelium of large intestine.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Elliptocytosis 1
    MedGen: C2678497 OMIM: 611804 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (EPB41) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1 (EPB41) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of intestinal absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in spectrin-associated cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein 4.1
    Names
    EPB4.1
    P4.1
    band 4.1
    elliptocytosis 1, RH-linked
    erythrocyte surface protein band 4.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013344.1 RefSeqGene

      Range
      32479..237951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166005.2 → NP_001159477.1  protein 4.1 isoform 1

      See identical proteins and their annotated locations for NP_001159477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS53288.1
      UniProtKB/Swiss-Prot
      B1ALH8, B1ALH9, D3DPM9, D3DPN0, P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579
      UniProtKB/TrEMBL
      Q59F12
      Related
      ENSP00000362904.1, ENST00000373798.5
      Conserved Domains (5) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668 → 715
      SAB; SAB domain
      pfam05902
      Location:754 → 860
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    2. NM_001166006.2 → NP_001159478.1  protein 4.1 isoform 3

      See identical proteins and their annotated locations for NP_001159478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 5' and 3' ends, and is missing an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL009181, BC039079, DA480006
      Consensus CDS
      CCDS53289.1
      UniProtKB/TrEMBL
      A0A2R8Y6G5
      Related
      ENSP00000362903.1, ENST00000373797.2
      Conserved Domains (6) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:653 → 699
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    3. NM_001166007.2 → NP_001159479.1  protein 4.1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate acceptor splice site at an exon at the 5' end, and is missing three short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (5) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, BC113841
      Consensus CDS
      CCDS85947.1
      UniProtKB/TrEMBL
      A0A2R8Y7Y3, Q4VB86
      Related
      ENSP00000496326.1, ENST00000647103.1
      Conserved Domains (7) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87 → 192
      FERM_M; FERM central domain
      pfam04382
      Location:406 → 450
      SAB; SAB domain
      pfam05902
      Location:491 → 597
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)
      pfam09379
      Location:5 → 65
      FERM_N; FERM N-terminal domain

    4. NM_001376013.1 → NP_001362942.1  protein 4.1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS53288.1
      UniProtKB/Swiss-Prot
      B1ALH8, B1ALH9, D3DPM9, D3DPN0, P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579
      UniProtKB/TrEMBL
      Q59F12
      Related
      ENSP00000345259.4, ENST00000343067.9
      Conserved Domains (5) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668 → 715
      SAB; SAB domain
      pfam05902
      Location:754 → 860
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    5. NM_001376014.1 → NP_001362943.1  protein 4.1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90900.1
      UniProtKB/TrEMBL
      A0A2U3TZH6, Q59F12
      Related
      ENSP00000317597.8, ENST00000349460.9
      Conserved Domains (5) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:633 → 680
      SAB; SAB domain
      pfam05902
      Location:731 → 837
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    6. NM_001376015.1 → NP_001362944.1  protein 4.1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (5) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:633 → 680
      SAB; SAB domain
      pfam05902
      Location:719 → 825
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    7. NM_001376016.1 → NP_001362945.1  protein 4.1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90899.1
      UniProtKB/TrEMBL
      A0A3B3IU06, A0A994J847
      Related
      ENSP00000516349.1, ENST00000706361.1
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668 → 715
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    8. NM_001376017.1 → NP_001362946.1  protein 4.1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90898.1
      UniProtKB/TrEMBL
      A0A2R8Y570, A0A2R8Y5Z6
      Related
      ENSP00000494945.1, ENST00000644600.1
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668 → 715
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    9. NM_001376018.1 → NP_001362947.1  protein 4.1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y570
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:667 → 714
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    10. NM_001376019.1 → NP_001362948.1  protein 4.1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90897.1
      UniProtKB/TrEMBL
      A0A2R8Y570, A0A2R8Y5G2
      Related
      ENSP00000494435.1, ENST00000643604.1
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668 → 715
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    11. NM_001376020.1 → NP_001362949.1  protein 4.1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y570
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:667 → 714
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    12. NM_001376021.1 → NP_001362950.1  protein 4.1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y570
      Conserved Domains (4) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:615 → 661
      SAB; SAB domain
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)

    13. NM_001376022.1 → NP_001362951.1  protein 4.1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90901.1
      UniProtKB/TrEMBL
      A0A2R8YD30, Q4VB86
      Related
      ENSP00000494212.1, ENST00000642937.2
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459 → 506
      SAB; SAB domain
      pfam05902
      Location:545 → 651
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    14. NM_001376023.1 → NP_001362952.1  protein 4.1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y7N0
      Related
      ENSP00000496138.1, ENST00000646189.1
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459 → 506
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    15. NM_001376024.1 → NP_001362953.1  protein 4.1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y420
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459 → 506
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    16. NM_001376025.1 → NP_001362954.1  protein 4.1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y420
      Related
      ENSP00000493575.1, ENST00000646800.1
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459 → 506
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    17. NM_001376026.1 → NP_001362955.1  protein 4.1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS90902.1
      UniProtKB/TrEMBL
      A0A2R8Y420, A0A2R8Y6D0
      Related
      ENSP00000495138.1, ENST00000644342.1
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:423 → 470
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    18. NM_001376027.1 → NP_001362956.1  protein 4.1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y7N0
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:406 → 452
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    19. NM_001376028.1 → NP_001362957.1  protein 4.1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      UniProtKB/TrEMBL
      A0A2R8Y7N0
      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:405 → 451
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    20. NM_004437.4 → NP_004428.1  protein 4.1 isoform 6

      See identical proteins and their annotated locations for NP_004428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate acceptor splice site at an exon at the 5' end, and is missing several short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (6) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, AL138785, BC039079, M14993
      Consensus CDS
      CCDS331.1
      UniProtKB/TrEMBL
      Q4VB86
      Related
      ENSP00000362906.3, ENST00000373800.7
      Conserved Domains (7) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87 → 192
      FERM_M; FERM central domain
      pfam04382
      Location:425 → 471
      SAB; SAB domain
      pfam05902
      Location:512 → 584
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)
      pfam09379
      Location:5 → 65
      FERM_N; FERM N-terminal domain

    21. NM_203342.3 → NP_976217.1  protein 4.1 isoform 4

      See identical proteins and their annotated locations for NP_976217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon at the 5' end, and is missing an internal, in-frame coding exon compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (4) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, AL138785, BC039079, J03796
      UniProtKB/TrEMBL
      Q4VB86
      Conserved Domains (7) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87 → 192
      FERM_M; FERM central domain
      pfam04382
      Location:444 → 490
      SAB; SAB domain
      pfam05902
      Location:531 → 637
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)
      pfam09379
      Location:5 → 65
      FERM_N; FERM N-terminal domain

    22. NM_203343.3 → NP_976218.1  protein 4.1 isoform 2

      See identical proteins and their annotated locations for NP_976218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing several short, internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, J03796
      Consensus CDS
      CCDS330.1
      UniProtKB/TrEMBL
      Q59F12
      Related
      ENSP00000290100.6, ENST00000347529.7
      Conserved Domains (6) summary
      smart00295
      Location:211 → 366
      B41; Band 4.1 homologues
      cd13184
      Location:361 → 454
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:261 → 366
      FERM_M; FERM central domain
      pfam04382
      Location:580 → 624
      SAB; SAB domain
      pfam05902
      Location:665 → 771
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:464 → 506
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28887100..29120041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245760.2 → XP_005245817.1  protein 4.1 isoform X17

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:667 → 713
      SAB; SAB domain
      pfam05902
      Location:771 → 877
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    2. XM_005245753.2 → XP_005245810.1  protein 4.1 isoform X1

      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:667 → 713
      SAB; SAB domain
      pfam05902
      Location:904 → 1010
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    3. XM_047449004.1 → XP_047304960.1  protein 4.1 isoform X26

      UniProtKB/TrEMBL
      Q59F12

    4. XM_005245768.2 → XP_005245825.1  protein 4.1 isoform X30

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:667 → 713
      SAB; SAB domain
      pfam05902
      Location:731 → 817
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    5. XM_047448981.1 → XP_047304937.1  protein 4.1 isoform X18

      UniProtKB/TrEMBL
      Q59F12

    6. XM_047448937.1 → XP_047304893.1  protein 4.1 isoform X3

      UniProtKB/TrEMBL
      Q59F12

    7. XM_047448961.1 → XP_047304917.1  protein 4.1 isoform X9

      UniProtKB/TrEMBL
      Q59F12

    8. XM_005245763.2 → XP_005245820.1  protein 4.1 isoform X20

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:653 → 699
      SAB; SAB domain
      pfam05902
      Location:740 → 846
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    9. XM_047449028.1 → XP_047304984.1  protein 4.1 isoform X32

      UniProtKB/TrEMBL
      Q59F12

    10. XM_047449035.1 → XP_047304991.1  protein 4.1 isoform X35

      UniProtKB/TrEMBL
      Q59F12

    11. XM_005245757.2 → XP_005245814.1  protein 4.1 isoform X7

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:633 → 678
      SAB; SAB domain
      pfam05902
      Location:869 → 975
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    12. XM_047448967.1 → XP_047304923.1  protein 4.1 isoform X14

      UniProtKB/TrEMBL
      Q59F12

    13. XM_047449045.1 → XP_047305001.1  protein 4.1 isoform X39

      UniProtKB/TrEMBL
      Q59F12

    14. XM_047449049.1 → XP_047305005.1  protein 4.1 isoform X43

      UniProtKB/TrEMBL
      Q59F12

    15. XM_047448994.1 → XP_047304950.1  protein 4.1 isoform X22

      UniProtKB/TrEMBL
      Q59F12

    16. XM_047448948.1 → XP_047304904.1  protein 4.1 isoform X5

      UniProtKB/TrEMBL
      Q59F12

    17. XM_047448965.1 → XP_047304921.1  protein 4.1 isoform X12

      UniProtKB/TrEMBL
      Q59F12

    18. XM_005245764.2 → XP_005245821.1  protein 4.1 isoform X24

      See identical proteins and their annotated locations for XP_005245821.1

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:634 → 680
      SAB; SAB domain
      pfam05902
      Location:721 → 827
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    19. XM_047449041.1 → XP_047304997.1  protein 4.1 isoform X37

      UniProtKB/TrEMBL
      Q59F12

    20. XM_047449047.1 → XP_047305003.1  protein 4.1 isoform X41

      UniProtKB/TrEMBL
      Q59F12

    21. XM_047449018.1 → XP_047304974.1  protein 4.1 isoform X29

      UniProtKB/TrEMBL
      Q59F12

    22. XM_047448962.1 → XP_047304918.1  protein 4.1 isoform X10

      UniProtKB/TrEMBL
      Q59F12

    23. XM_047448975.1 → XP_047304931.1  protein 4.1 isoform X16

      UniProtKB/TrEMBL
      Q59F12

    24. XM_005245769.2 → XP_005245826.1  protein 4.1 isoform X33

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:615 → 659
      SAB; SAB domain
      pfam05902
      Location:700 → 806
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    25. XM_047449056.1 → XP_047305012.1  protein 4.1 isoform X45

      UniProtKB/TrEMBL
      Q59F12

    26. XM_005245774.2 → XP_005245831.1  protein 4.1 isoform X47

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:615 → 659
      SAB; SAB domain
      pfam05902
      Location:677 → 763
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    27. XM_047448932.1 → XP_047304888.1  protein 4.1 isoform X2

    28. XM_047448985.1 → XP_047304941.1  protein 4.1 isoform X19

      UniProtKB/TrEMBL
      Q59F12

    29. XM_047449012.1 → XP_047304968.1  protein 4.1 isoform X27

      UniProtKB/TrEMBL
      Q59F12

    30. XM_047449026.1 → XP_047304982.1  protein 4.1 isoform X31

      UniProtKB/TrEMBL
      Q59F12

    31. XM_047448939.1 → XP_047304895.1  protein 4.1 isoform X4

      UniProtKB/TrEMBL
      Q59F12

    32. XM_047448992.1 → XP_047304948.1  protein 4.1 isoform X21

      UniProtKB/TrEMBL
      Q59F12

    33. XM_047449039.1 → XP_047304995.1  protein 4.1 isoform X36

      UniProtKB/TrEMBL
      Q59F12

    34. XM_047448957.1 → XP_047304913.1  protein 4.1 isoform X8

      UniProtKB/TrEMBL
      Q59F12

    35. XM_047448969.1 → XP_047304925.1  protein 4.1 isoform X15

      UniProtKB/TrEMBL
      Q59F12

    36. XM_047449016.1 → XP_047304972.1  protein 4.1 isoform X28

      UniProtKB/TrEMBL
      Q59F12

    37. XM_047449046.1 → XP_047305002.1  protein 4.1 isoform X40

      UniProtKB/TrEMBL
      Q59F12

    38. XM_047449053.1 → XP_047305009.1  protein 4.1 isoform X44

      UniProtKB/TrEMBL
      Q59F12

    39. XM_047448995.1 → XP_047304951.1  protein 4.1 isoform X23

      UniProtKB/TrEMBL
      Q59F12

    40. XM_047448950.1 → XP_047304906.1  protein 4.1 isoform X6

      UniProtKB/TrEMBL
      Q59F12

    41. XM_047448966.1 → XP_047304922.1  protein 4.1 isoform X13

      UniProtKB/TrEMBL
      Q59F12

    42. XM_047448997.1 → XP_047304953.1  protein 4.1 isoform X25

      UniProtKB/TrEMBL
      Q59F12

    43. XM_047449043.1 → XP_047304999.1  protein 4.1 isoform X38

      UniProtKB/TrEMBL
      Q59F12

    44. XM_047449048.1 → XP_047305004.1  protein 4.1 isoform X42

      UniProtKB/TrEMBL
      Q59F12

    45. XM_047448964.1 → XP_047304920.1  protein 4.1 isoform X11

      UniProtKB/TrEMBL
      Q59F12

    46. XM_005245770.2 → XP_005245827.1  protein 4.1 isoform X34

      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:211 → 401
      B41; Band 4.1 homologues
      cd13184
      Location:396 → 489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296 → 401
      FERM_M; FERM central domain
      pfam04382
      Location:614 → 658
      SAB; SAB domain
      pfam05902
      Location:699 → 805
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499 → 541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214 → 274
      FERM_N; FERM N-terminal domain

    47. XM_047449060.1 → XP_047305016.1  protein 4.1 isoform X46

      UniProtKB/TrEMBL
      Q59F12

    48. XM_047449061.1 → XP_047305017.1  protein 4.1 isoform X48

      UniProtKB/TrEMBL
      Q59F12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28729007..28962697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335001.1 → XP_054190976.1  protein 4.1 isoform X17

      UniProtKB/TrEMBL
      Q59F12

    2. XM_054334985.1 → XP_054190960.1  protein 4.1 isoform X1

    3. XM_054335010.1 → XP_054190985.1  protein 4.1 isoform X26

      UniProtKB/TrEMBL
      Q59F12

    4. XM_054335014.1 → XP_054190989.1  protein 4.1 isoform X30

      UniProtKB/TrEMBL
      Q59F12

    5. XM_054335002.1 → XP_054190977.1  protein 4.1 isoform X18

      UniProtKB/TrEMBL
      Q59F12

    6. XM_054334987.1 → XP_054190962.1  protein 4.1 isoform X3

      UniProtKB/TrEMBL
      Q59F12

    7. XM_054334993.1 → XP_054190968.1  protein 4.1 isoform X9

      UniProtKB/TrEMBL
      Q59F12

    8. XM_054335004.1 → XP_054190979.1  protein 4.1 isoform X20

      UniProtKB/TrEMBL
      Q59F12

    9. XM_054335016.1 → XP_054190991.1  protein 4.1 isoform X32

      UniProtKB/TrEMBL
      Q59F12

    10. XM_054335019.1 → XP_054190994.1  protein 4.1 isoform X35

      UniProtKB/TrEMBL
      Q59F12

    11. XM_054334991.1 → XP_054190966.1  protein 4.1 isoform X7

      UniProtKB/TrEMBL
      Q59F12

    12. XM_054334998.1 → XP_054190973.1  protein 4.1 isoform X14

      UniProtKB/TrEMBL
      Q59F12

    13. XM_054335023.1 → XP_054190998.1  protein 4.1 isoform X39

      UniProtKB/TrEMBL
      Q59F12

    14. XM_054335027.1 → XP_054191002.1  protein 4.1 isoform X43

      UniProtKB/TrEMBL
      Q59F12

    15. XM_054335006.1 → XP_054190981.1  protein 4.1 isoform X22

      UniProtKB/TrEMBL
      Q59F12

    16. XM_054334989.1 → XP_054190964.1  protein 4.1 isoform X5

      UniProtKB/TrEMBL
      Q59F12

    17. XM_054334996.1 → XP_054190971.1  protein 4.1 isoform X12

      UniProtKB/TrEMBL
      Q59F12

    18. XM_054335008.1 → XP_054190983.1  protein 4.1 isoform X24

      UniProtKB/TrEMBL
      Q59F12

    19. XM_054335021.1 → XP_054190996.1  protein 4.1 isoform X37

      UniProtKB/TrEMBL
      Q59F12

    20. XM_054335025.1 → XP_054191000.1  protein 4.1 isoform X41

      UniProtKB/TrEMBL
      Q59F12

    21. XM_054335013.1 → XP_054190988.1  protein 4.1 isoform X29

      UniProtKB/TrEMBL
      Q59F12

    22. XM_054334994.1 → XP_054190969.1  protein 4.1 isoform X10

      UniProtKB/TrEMBL
      Q59F12

    23. XM_054335000.1 → XP_054190975.1  protein 4.1 isoform X16

      UniProtKB/TrEMBL
      Q59F12

    24. XM_054335017.1 → XP_054190992.1  protein 4.1 isoform X33

      UniProtKB/TrEMBL
      Q59F12

    25. XM_054335029.1 → XP_054191004.1  protein 4.1 isoform X45

      UniProtKB/TrEMBL
      Q59F12

    26. XM_054335031.1 → XP_054191006.1  protein 4.1 isoform X47

      UniProtKB/TrEMBL
      Q59F12

    27. XM_054334986.1 → XP_054190961.1  protein 4.1 isoform X2

    28. XM_054335003.1 → XP_054190978.1  protein 4.1 isoform X19

      UniProtKB/TrEMBL
      Q59F12

    29. XM_054335011.1 → XP_054190986.1  protein 4.1 isoform X27

      UniProtKB/TrEMBL
      Q59F12

    30. XM_054335015.1 → XP_054190990.1  protein 4.1 isoform X31

      UniProtKB/TrEMBL
      Q59F12

    31. XM_054334988.1 → XP_054190963.1  protein 4.1 isoform X4

      UniProtKB/TrEMBL
      Q59F12

    32. XM_054335005.1 → XP_054190980.1  protein 4.1 isoform X21

      UniProtKB/TrEMBL
      Q59F12

    33. XM_054335020.1 → XP_054190995.1  protein 4.1 isoform X36

      UniProtKB/TrEMBL
      Q59F12

    34. XM_054334992.1 → XP_054190967.1  protein 4.1 isoform X8

      UniProtKB/TrEMBL
      Q59F12

    35. XM_054334999.1 → XP_054190974.1  protein 4.1 isoform X15

      UniProtKB/TrEMBL
      Q59F12

    36. XM_054335012.1 → XP_054190987.1  protein 4.1 isoform X28

      UniProtKB/TrEMBL
      Q59F12

    37. XM_054335024.1 → XP_054190999.1  protein 4.1 isoform X40

      UniProtKB/TrEMBL
      Q59F12

    38. XM_054335028.1 → XP_054191003.1  protein 4.1 isoform X44

      UniProtKB/TrEMBL
      Q59F12

    39. XM_054335007.1 → XP_054190982.1  protein 4.1 isoform X23

      UniProtKB/TrEMBL
      Q59F12

    40. XM_054334990.1 → XP_054190965.1  protein 4.1 isoform X6

      UniProtKB/TrEMBL
      Q59F12

    41. XM_054334997.1 → XP_054190972.1  protein 4.1 isoform X13

      UniProtKB/TrEMBL
      Q59F12

    42. XM_054335009.1 → XP_054190984.1  protein 4.1 isoform X25

      UniProtKB/TrEMBL
      Q59F12

    43. XM_054335022.1 → XP_054190997.1  protein 4.1 isoform X38

      UniProtKB/TrEMBL
      Q59F12

    44. XM_054335026.1 → XP_054191001.1  protein 4.1 isoform X42

      UniProtKB/TrEMBL
      Q59F12

    45. XM_054334995.1 → XP_054190970.1  protein 4.1 isoform X11

      UniProtKB/TrEMBL
      Q59F12

    46. XM_054335018.1 → XP_054190993.1  protein 4.1 isoform X34

      UniProtKB/TrEMBL
      Q59F12

    47. XM_054335030.1 → XP_054191005.1  protein 4.1 isoform X46

      UniProtKB/TrEMBL
      Q59F12

    48. XM_054335032.1 → XP_054191007.1  protein 4.1 isoform X48

      UniProtKB/TrEMBL
      Q59F12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11171.4 GenPept UniProtKB/Swiss-Prot:P11171

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