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    NT5C2 5'-nucleotidase, cytosolic II [ Homo sapiens (human) ]

    Gene ID: 22978, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NT5C2provided by HGNC
    Official Full Name
    5'-nucleotidase, cytosolic IIprovided by HGNC
    Primary source
    HGNC:HGNC:8022
    See related
    Ensembl:ENSG00000076685 MIM:600417; AllianceGenome:HGNC:8022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GMP; NT5B; PNT5; SPG45; SPG65; cN-II
    Summary
    This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.3), esophagus (RPKM 12.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    See NT5C2 in Genome Data Viewer
    Location:
    10q24.32-q24.33
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103088017..103193272, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103974258..104079521, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104847774..104953029, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BORCS7-ASMT readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104657816-104658316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104658317-104658817 Neighboring gene uncharacterized LOC107984265 Neighboring gene arsenite methyltransferase Neighboring gene ribosomal protein L22 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 3077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104677004-104677690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104677691-104678377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2775 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene MPRA-validated peak1082 silencer Neighboring gene Sharpr-MPRA regulatory region 2614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3953 Neighboring gene ribosomal protein S15a pseudogene 29 Neighboring gene MARCKS like 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104946667-104947166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104946165-104946666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104951770-104952458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104952459-104953145 Neighboring gene CRISPRi-validated cis-regulatory element chr10.3946 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:104962099-104962305 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104964236-104964895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:104964896-104965554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104990595-104991592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104991593-104992590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3955 Neighboring gene ST13, Hsp70 interacting protein pseudogene 13 Neighboring gene ribulose-5-phosphate-3-epimerase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. NT5C2 novel splicing variant expands the phenotypic spectrum of Spastic Paraplegia (SPG45): case report of a new member of thin corpus callosum SPG-Subgroup. Elsaid MF, et al. BMC Med Genet, 2017 Mar 21. PMID 28327087, Free PMC Article
    2. Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia. Jiang C, et al. Clin Pharmacol Ther, 2021 Jun. PMID 33124053, Free PMC Article
    3. Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population. Xie X, et al. Asian J Psychiatr, 2020 Oct. PMID 32590138
    4. NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease. Chen X, et al. Public Health Genomics, 2020. PMID 32541135
    5. Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia. Barz MJ, et al. Blood, 2020 Mar 19. PMID 31971569, Free PMC Article

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
      Title: Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
    2. Silencing of circ-NT5C2 retards the progression of IL-1beta-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.
      Title: Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.
    3. Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
      Title: Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
    4. NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
      Title: NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
    5. Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
      Title: Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
    6. Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
      Title: Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
    7. Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
      Title: Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
    8. Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population.
      Title: Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population.
    9. CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
      Title: CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
    10. NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease.
      Title: NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hereditary spastic paraplegia 45
    MedGen: C3888209 OMIM: 613162 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A comprehensive family-based replication study of schizophrenia genes.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of 5'-nucleotidase, cytosolic II (NT5C2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-nucleotidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP 5'-nucleotidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables IMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside phosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic purine 5'-nucleotidase
    Names
    5'-nucleotidase (purine), cytosolic type B
    IMP-specific 5'-NT
    cytosolic IMP/GMP-specific 5'-nucleotidase
    cytosolic nucleoside phosphotransferase 5'N
    epididymis secretory sperm binding protein
    high Km 5'-nucleotidase
    spastic paraplegia 45 (autosomal recessive)
    NP_001127845.1
    NP_001338098.1
    NP_001338099.1
    NP_001338100.1
    NP_001338101.1
    NP_001338102.1
    NP_001338103.1
    NP_001338104.1
    NP_001338105.1
    NP_001338106.1
    NP_001338107.1
    NP_001338108.1
    NP_001338109.1
    NP_001338110.1
    NP_001338111.1
    NP_001338112.1
    NP_001338113.1
    NP_001338114.1
    NP_001338115.1
    NP_001338116.1
    NP_001338117.1
    NP_001338118.1
    NP_001338119.1
    NP_001338120.1
    NP_001338121.1
    NP_001338122.1
    NP_001338123.1
    NP_001338124.1
    NP_001338125.1
    NP_001338126.1
    NP_036361.1
    XP_005269694.1
    XP_011537839.1
    XP_016871436.1
    XP_024303669.1
    XP_024303670.1
    XP_024303671.1
    XP_047280800.1
    XP_047280801.1
    XP_047280802.1
    XP_047280803.1
    XP_047280804.1
    XP_047280805.1
    XP_047280806.1
    XP_047280807.1
    XP_047280808.1
    XP_047280809.1
    XP_047280810.1
    XP_047280811.1
    XP_047280812.1
    XP_047280813.1
    XP_047280814.1
    XP_047280815.1
    XP_054221213.1
    XP_054221214.1
    XP_054221215.1
    XP_054221216.1
    XP_054221217.1
    XP_054221218.1
    XP_054221219.1
    XP_054221220.1
    XP_054221221.1
    XP_054221222.1
    XP_054221223.1
    XP_054221224.1
    XP_054221225.1
    XP_054221226.1
    XP_054221227.1
    XP_054221228.1
    XP_054221229.1
    XP_054221230.1
    XP_054221231.1
    XP_054221232.1
    XP_054221233.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042272.1 RefSeqGene

      Range
      5001..110290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134373.3 → NP_001127845.1  cytosolic purine 5'-nucleotidase isoform 1

      See identical proteins and their annotated locations for NP_001127845.1

      Status: REVIEWED

      Source sequence(s)
      AL139817, AL360001
      Consensus CDS
      CCDS7544.1
      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2
      Related
      ENSP00000339479.5, ENST00000343289.9
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    2. NM_001351169.2 → NP_001338098.1  cytosolic purine 5'-nucleotidase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL139817, AL360001
      Consensus CDS
      CCDS7544.1
      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2
      Related
      ENSP00000383960.3, ENST00000404739.8
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    3. NM_001351170.2 → NP_001338099.1  cytosolic purine 5'-nucleotidase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DB077941, DB169780
      Consensus CDS
      CCDS91340.1
      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    4. NM_001351171.2 → NP_001338100.1  cytosolic purine 5'-nucleotidase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BP241199, BU618027, DB077941
      Consensus CDS
      CCDS91340.1
      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    5. NM_001351172.2 → NP_001338101.1  cytosolic purine 5'-nucleotidase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DB077941, DB164777
      Consensus CDS
      CCDS91340.1
      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2
      Related
      ENSP00000502816.1, ENST00000674860.1
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    6. NM_001351173.2 → NP_001338102.1  cytosolic purine 5'-nucleotidase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, BU622015, DB077941, DB164777
      Consensus CDS
      CCDS91340.1
      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    7. NM_001351174.1 → NP_001338103.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK295593, BC001595, BU618027, DC348363
      Consensus CDS
      CCDS91339.1
      UniProtKB/TrEMBL
      A8K6K2
      Related
      ENSP00000502215.1, ENST00000675985.1
      Conserved Domains (1) summary
      pfam05761
      Location:14 → 459
      5_nucleotid; 5' nucleotidase family

    8. NM_001351175.2 → NP_001338104.1  cytosolic purine 5'-nucleotidase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK291667, AL360001, BC001595, BU618027, DB164777
      UniProtKB/TrEMBL
      A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:27 → 457
      5_nucleotid; 5' nucleotidase family

    9. NM_001351176.2 → NP_001338105.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA724300
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    10. NM_001351177.2 → NP_001338106.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA201591, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    11. NM_001351178.2 → NP_001338107.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA343552, DA408606, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    12. NM_001351179.2 → NP_001338108.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BU622015, BX648078, DA215274
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    13. NM_001351180.2 → NP_001338109.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, AL040624, BC001595, BU618027, BX648078, DA493263, DB169780, DB178099
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    14. NM_001351181.2 → NP_001338110.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DB127914, DB169780, DB443441
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    15. NM_001351182.2 → NP_001338111.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA184708, DA724300
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    16. NM_001351183.2 → NP_001338112.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA208418, DB169780, DB178099, DB261846
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    17. NM_001351184.2 → NP_001338113.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA724300, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    18. NM_001351185.2 → NP_001338114.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA724300, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    19. NM_001351186.2 → NP_001338115.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA223605, DA724300, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    20. NM_001351187.2 → NP_001338116.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA223605, DA408606, DA724300, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    21. NM_001351188.2 → NP_001338117.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BX648078, DA335453, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    22. NM_001351189.2 → NP_001338118.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BE936228, BU618027, BU622015, BX648078, DA746739, DB178099, DB261846
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    23. NM_001351190.2 → NP_001338119.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, BU622015, BX648078, DB178099, DB261846, DB287849
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    24. NM_001351191.1 → NP_001338120.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA201591, DB127914, DC348363
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    25. NM_001351192.1 → NP_001338121.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DB097637, DB127914, DC348363
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    26. NM_001351193.1 → NP_001338122.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BP212875, BU618027, DB097637, DB127914, DC348363
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    27. NM_001351194.2 → NP_001338123.1  cytosolic purine 5'-nucleotidase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA208418, DB169780, DB178099, DB261846
      Conserved Domains (1) summary
      cl17687
      Location:1 → 250
      5_nucleotid; 5' nucleotidase family

    28. NM_001351195.2 → NP_001338124.1  cytosolic purine 5'-nucleotidase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA184708, DA208418, DB178099, DB261846
      Conserved Domains (1) summary
      cl17687
      Location:1 → 250
      5_nucleotid; 5' nucleotidase family

    29. NM_001351196.2 → NP_001338125.1  cytosolic purine 5'-nucleotidase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA208418, DA223605, DB169780, DB178099, DB261846
      Conserved Domains (1) summary
      cl17687
      Location:1 → 250
      5_nucleotid; 5' nucleotidase family

    30. NM_001351197.2 → NP_001338126.1  cytosolic purine 5'-nucleotidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK291667, BC001595, BU618027, DA408606, DA724300, DB169780
      Conserved Domains (1) summary
      cl17687
      Location:1 → 297
      5_nucleotid; 5' nucleotidase family

    31. NM_012229.5 → NP_036361.1  cytosolic purine 5'-nucleotidase isoform 1

      See identical proteins and their annotated locations for NP_036361.1

      Status: REVIEWED

      Source sequence(s)
      BC001595, BU618027, DA879821
      Consensus CDS
      CCDS7544.1
      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      103088017..103193272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424854.1 → XP_047280810.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    2. XM_047424852.1 → XP_047280808.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2

    3. XM_047424856.1 → XP_047280812.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    4. XM_047424853.1 → XP_047280809.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2

    5. XM_047424855.1 → XP_047280811.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    6. XM_011539537.2 → XP_011537839.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 439
      5_nucleotid; 5' nucleotidase family

    7. XM_047424845.1 → XP_047280801.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    8. XM_047424847.1 → XP_047280803.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    9. XM_024447901.2 → XP_024303669.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    10. XM_047424850.1 → XP_047280806.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    11. XM_047424846.1 → XP_047280802.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    12. XM_047424849.1 → XP_047280805.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    13. XM_047424844.1 → XP_047280800.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    14. XM_047424848.1 → XP_047280804.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    15. XM_024447902.2 → XP_024303670.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    16. XM_005269637.6 → XP_005269694.1  cytosolic purine 5'-nucleotidase isoform X3

      See identical proteins and their annotated locations for XP_005269694.1

      UniProtKB/TrEMBL
      A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:14 → 467
      5_nucleotid; 5' nucleotidase family

    17. XM_047424851.1 → XP_047280807.1  cytosolic purine 5'-nucleotidase isoform X5

      UniProtKB/TrEMBL
      A8K6K2

    18. XM_047424857.1 → XP_047280813.1  cytosolic purine 5'-nucleotidase isoform X9

    19. XM_047424858.1 → XP_047280814.1  cytosolic purine 5'-nucleotidase isoform X9

    20. XM_017015947.3 → XP_016871436.1  cytosolic purine 5'-nucleotidase isoform X4

      UniProtKB/TrEMBL
      A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:27 → 465
      5_nucleotid; 5' nucleotidase family

    21. XM_024447903.2 → XP_024303671.1  cytosolic purine 5'-nucleotidase isoform X6

      UniProtKB/TrEMBL
      A8K6K2
      Conserved Domains (1) summary
      pfam05761
      Location:24 → 452
      5_nucleotid; 5' nucleotidase family

    22. XM_047424859.1 → XP_047280815.1  cytosolic purine 5'-nucleotidase isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103974258..104079521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365254.1 → XP_054221229.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    2. XM_054365252.1 → XP_054221227.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2

    3. XM_054365256.1 → XP_054221231.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    4. XM_054365253.1 → XP_054221228.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2

    5. XM_054365255.1 → XP_054221230.1  cytosolic purine 5'-nucleotidase isoform X8

      UniProtKB/TrEMBL
      A8K6K2

    6. XM_054365251.1 → XP_054221226.1  cytosolic purine 5'-nucleotidase isoform X7

      UniProtKB/TrEMBL
      A8K6K2

    7. XM_054365240.1 → XP_054221215.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    8. XM_054365243.1 → XP_054221218.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    9. XM_054365239.1 → XP_054221214.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    10. XM_054365246.1 → XP_054221221.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    11. XM_054365241.1 → XP_054221216.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    12. XM_054365245.1 → XP_054221220.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    13. XM_054365238.1 → XP_054221213.1  cytosolic purine 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHP0, A8K6K2

    14. XM_054365244.1 → XP_054221219.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    15. XM_054365242.1 → XP_054221217.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      B7Z382, D3DR91, P49902, Q5JUV5
      UniProtKB/TrEMBL
      A0A384MED8, A8K6K2

    16. XM_054365247.1 → XP_054221222.1  cytosolic purine 5'-nucleotidase isoform X3

      UniProtKB/TrEMBL
      A8K6K2

    17. XM_054365249.1 → XP_054221224.1  cytosolic purine 5'-nucleotidase isoform X5

      UniProtKB/TrEMBL
      A8K6K2

    18. XM_054365257.1 → XP_054221232.1  cytosolic purine 5'-nucleotidase isoform X9

    19. XM_054365248.1 → XP_054221223.1  cytosolic purine 5'-nucleotidase isoform X4

      UniProtKB/TrEMBL
      A8K6K2

    20. XM_054365250.1 → XP_054221225.1  cytosolic purine 5'-nucleotidase isoform X6

      UniProtKB/TrEMBL
      A8K6K2

    21. XM_054365258.1 → XP_054221233.1  cytosolic purine 5'-nucleotidase isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49902.1 GenPept UniProtKB/Swiss-Prot:P49902

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