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    ANAPC15 anaphase promoting complex subunit 15 [ Homo sapiens (human) ]

    Gene ID: 25906, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ANAPC15provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 15provided by HGNC
    Primary source
    HGNC:HGNC:24531
    See related
    Ensembl:ENSG00000110200 MIM:614717; AllianceGenome:HGNC:24531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC15; HSPC020; C11orf51
    Summary
    Involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.8), testis (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANAPC15 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72106372..72112780, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72033262..72039670, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71817418..71823826, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3713 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71814909-71815429 Neighboring gene uncharacterized LOC124902837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823011-71823548 Neighboring gene transmembrane O-methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823549-71824086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71824087-71824624 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71849877-71850378 Neighboring gene folate receptor gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. Li Q, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27601667, Free PMC Article
    2. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Castro A, et al. Oncogene, 2005 Jan 13. PMID 15678131
    3. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Uzunova K, et al. Nat Struct Mol Biol, 2012 Nov. PMID 23007861, Free PMC Article
    4. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Yau RG, et al. Cell, 2017 Nov 2. PMID 29033132, Free PMC Article
    5. Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Sedgwick GG, et al. Oncogene, 2013 Sep 26. PMID 23160376, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible
      Title: WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.
    2. Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
      Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
    3. APC15 is required for anaphase-promoting complex/cyclosome-bound mitotic checkpoint complex-dependent CDC20 autoubiquitylation and degradation and for timely anaphase initiation.
      Title: APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564M082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278485.2 → NP_001265414.1  anaphase-promoting complex subunit 15 isoform a

      See identical proteins and their annotated locations for NP_001265414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
      Source sequence(s)
      AF077206, BG752082
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000443645.1, ENST00000545680.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    2. NM_001278486.2 → NP_001265415.1  anaphase-promoting complex subunit 15 isoform a

      See identical proteins and their annotated locations for NP_001265415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
      Source sequence(s)
      AK222622, AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000439403.1, ENST00000543587.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    3. NM_001278487.2 → NP_001265416.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206, AP000812, BG764016
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000440002.1, ENST00000538393.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    4. NM_001278488.2 → NP_001265417.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206, AP000812, BU532056
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000443383.1, ENST00000535503.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    5. NM_001278489.2 → NP_001265418.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206, CN306434
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000446412.1, ENST00000535234.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    6. NM_001278490.2 → NP_001265419.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206, BU930156
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000446383.1, ENST00000545944.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    7. NM_001278491.1 → NP_001265420.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206, AP000812, BE616852
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    8. NM_001278492.2 → NP_001265421.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000443911.1, ENST00000542531.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    9. NM_001278493.2 → NP_001265422.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    10. NM_001278494.2 → NP_001265423.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_001265423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000440983.1, ENST00000538919.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    11. NM_001330321.2 → NP_001317250.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) uses an alternate 3' terminal exon compared to variant 1. It encodes isoform c, which is longer than and has a distinct C-terminus compared to isoform a. Variants 12-17 all encode the same isoform (c).
      Source sequence(s)
      AP000812, HY166245
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Related
      ENSP00000437360.1, ENST00000543050.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    12. NM_001393427.1 → NP_001380356.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    13. NM_001393428.1 → NP_001380357.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    14. NM_001393429.1 → NP_001380358.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    15. NM_001393430.1 → NP_001380359.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    16. NM_001393431.1 → NP_001380360.1  anaphase-promoting complex subunit 15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS81593.1
      UniProtKB/TrEMBL
      G5EA39
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    17. NM_001393432.1 → NP_001380361.1  anaphase-promoting complex subunit 15 isoform d

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H6E4
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 60
      ANAPC15; Anaphase-promoting complex subunit 15

    18. NM_001393433.1 → NP_001380362.1  anaphase-promoting complex subunit 15 isoform d

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H6E4
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 60
      ANAPC15; Anaphase-promoting complex subunit 15

    19. NM_001393434.1 → NP_001380363.1  anaphase-promoting complex subunit 15 isoform d

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H6E4
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 60
      ANAPC15; Anaphase-promoting complex subunit 15

    20. NM_001393435.1 → NP_001380364.1  anaphase-promoting complex subunit 15 isoform d

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H6E4
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 60
      ANAPC15; Anaphase-promoting complex subunit 15

    21. NM_001393436.1 → NP_001380365.1  anaphase-promoting complex subunit 15 isoform d

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H6E4
      Related
      ENSP00000437683.1, ENST00000537644.5
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 60
      ANAPC15; Anaphase-promoting complex subunit 15

    22. NM_001393437.1 → NP_001380366.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    23. NM_001393438.1 → NP_001380367.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    24. NM_001393439.1 → NP_001380368.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    25. NM_001393440.1 → NP_001380369.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    26. NM_001393441.1 → NP_001380370.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    27. NM_001393442.1 → NP_001380371.1  anaphase-promoting complex subunit 15 isoform a

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS60880.1
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    28. NM_001393443.1 → NP_001380372.1  anaphase-promoting complex subunit 15 isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    29. NM_001393444.1 → NP_001380373.1  anaphase-promoting complex subunit 15 isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    30. NM_001393445.1 → NP_001380374.1  anaphase-promoting complex subunit 15 isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000812
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    31. NM_001393446.1 → NP_001380375.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    32. NM_001393447.1 → NP_001380376.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    33. NM_001393448.1 → NP_001380377.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    34. NM_001393449.1 → NP_001380378.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    35. NM_001393450.1 → NP_001380379.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    36. NM_001393451.1 → NP_001380380.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    37. NM_001393452.1 → NP_001380381.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    38. NM_001393453.1 → NP_001380382.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    39. NM_001393454.1 → NP_001380383.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    40. NM_001393455.1 → NP_001380384.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    41. NM_001393456.1 → NP_001380385.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    42. NM_001393457.1 → NP_001380386.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    43. NM_001393458.1 → NP_001380387.1  anaphase-promoting complex subunit 15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    44. NM_001393459.1 → NP_001380388.1  anaphase-promoting complex subunit 15 isoform f

      Status: VALIDATED

      Source sequence(s)
      AP000812
      Consensus CDS
      CCDS91530.1
      UniProtKB/TrEMBL
      F5GWM6
      Related
      ENSP00000441774.1, ENST00000502597.2

    45. NM_014042.3 → NP_054761.1  anaphase-promoting complex subunit 15 isoform b

      See identical proteins and their annotated locations for NP_054761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
      Source sequence(s)
      AF077206
      Consensus CDS
      CCDS8210.1
      UniProtKB/Swiss-Prot
      G3V1Q3, P60006, Q9CXK2, Q9Y269
      UniProtKB/TrEMBL
      F5H3R3
      Related
      ENSP00000227618.4, ENST00000227618.9
      Conserved Domains (1) summary
      pfam15243
      Location:4 → 62
      ANAPC15; Anaphase-promoting complex subunit 15

    RNA

    1. NR_171684.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000812

    2. NR_171685.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000812

    3. NR_171686.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000812

    4. NR_171687.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000812

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72106372..72112780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426723.1 → XP_047282679.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/TrEMBL
      F5H3R3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      72033262..72039670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368348.1 → XP_054224323.1  anaphase-promoting complex subunit 15 isoform X1

      UniProtKB/TrEMBL
      F5H3R3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60006.1 GenPept UniProtKB/Swiss-Prot:P60006

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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