IRF2BP1 interferon regulatory factor 2 binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IRF2BP1provided by HGNC
Official Full Name: interferon regulatory factor 2 binding protein 1provided by HGNC
Primary source: HGNC:HGNC:21728
See related: Ensembl:ENSG00000170604 MIM:615331; AllianceGenome:HGNC:21728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (45883608..45886141, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (48711051..48713583, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (46386866..46389399, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling.
Title: Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling.
IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter.
Title: IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.
PCTA (IRF2BP1) defines a new component of the TGF-beta signalling pathway that functions to facilitate Smad2 phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2-receptor complex.
Title: Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling.
Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2.
Title: Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 2-binding protein 1

Names: IRF-2-binding protein 1; probable E3 ubiquitin-protein ligase IRF2BP1; probable RING-type E3 ubiquitin transferase IRF2BP1

NP_056464.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015649.3 → NP_056464.1 interferon regulatory factor 2-binding protein 1

See identical proteins and their annotated locations for NP_056464.1

Status: VALIDATED

Source sequence(s)

AY278022, DA791039

Consensus CDS

CCDS12678.1

UniProtKB/Swiss-Prot

Q53EL7, Q6DC95, Q8IU81, Q9BRZ9, Q9Y4P4

UniProtKB/TrEMBL

B2RCD8

Related

ENSP00000307265.3, ENST00000302165.5

Conserved Domains (3) summary

cd16715
Location:501 → 556

vRING-HC_IRF2BP1; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1)

pfam11261
Location:8 → 59

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

NF033930
Location:330 → 422

pneumo_PspA; pneumococcal surface protein A