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    TOMM6 translocase of outer mitochondrial membrane 6 [ Homo sapiens (human) ]

    Gene ID: 100188893, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TOMM6provided by HGNC
    Official Full Name
    translocase of outer mitochondrial membrane 6provided by HGNC
    Primary source
    HGNC:HGNC:34528
    See related
    Ensembl:ENSG00000214736 MIM:616168; AllianceGenome:HGNC:34528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBTP; TOM6
    Summary
    Predicted to be involved in protein transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 63.4), kidney (RPKM 57.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TOMM6 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41787694..41789895)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41616256..41618460)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41755432..41757633)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41755120-41756119 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene Sharpr-MPRA regulatory region 15280 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene MPRA-validated peak5805 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41861872-41862386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:41862979-41863271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24529 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:41884515-41885714 Neighboring gene mediator complex subunit 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24530 Neighboring gene bystin like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. Chassin D, et al. Cancer Res, 1994 Oct 1. PMID 7923143
    2. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Kato H, et al. Biochem Biophys Res Commun, 2008 May 9. PMID 18331822
    3. Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. Gevaert K, et al. Proteomics, 2005 Sep. PMID 16097034
    4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
    5. Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner. García-Gutiérrez L, et al. Cell Death Dis, 2022 Aug 8. PMID 35941108, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The human counterparts of Tom5 and Tom6, together with the other components including Tom7, were identified in the preprotein translocase complex.
      Title: Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32622, DKFZp761H221

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TOM complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM6 homolog
    Names
    over-expressed breast tumor protein
    overexpressed breast tumor protein
    translocase of outer membrane 6 kDa subunit homolog
    translocase of outer mitochondrial membrane 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134493.2 → NP_001127965.1  mitochondrial import receptor subunit TOM6 homolog

      See identical proteins and their annotated locations for NP_001127965.1

      Status: REVIEWED

      Source sequence(s)
      AL365205
      Consensus CDS
      CCDS47424.1
      UniProtKB/Swiss-Prot
      B2DG15, Q96B49, Q9UH52
      Related
      ENSP00000381859.3, ENST00000398884.7
      Conserved Domains (1) summary
      pfam15184
      Location:1 → 74
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog

    2. NM_001382294.1 → NP_001369223.1  mitochondrial import receptor subunit TOM6 homolog

      Status: REVIEWED

      Source sequence(s)
      AL365205
      Consensus CDS
      CCDS47424.1
      UniProtKB/Swiss-Prot
      B2DG15, Q96B49, Q9UH52
      Related
      ENSP00000381856.3, ENST00000398881.4
      Conserved Domains (1) summary
      pfam15184
      Location:1 → 74
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41787694..41789895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      41616256..41618460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B49.1 GenPept UniProtKB/Swiss-Prot:Q96B49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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