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    NEUROG1 neurogenin 1 [ Homo sapiens (human) ]

    Gene ID: 4762, updated on 27-Nov-2024

    Summary

    Official Symbol
    NEUROG1provided by HGNC
    Official Full Name
    neurogenin 1provided by HGNC
    Primary source
    HGNC:HGNC:7764
    See related
    Ensembl:ENSG00000181965 MIM:601726; AllianceGenome:HGNC:7764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AKA; ngn1; CCDDRD; Math4C; bHLHa6; NEUROD3
    Summary
    Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See NEUROG1 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135534282..135535964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136061404..136063086, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134869972..134871654, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134784907-134785408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134785409-134785908 Neighboring gene uncharacterized LOC124901073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23175 Neighboring gene dendritic cell associated nuclear protein 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:134820245-134821093 Neighboring gene TIFA inhibitor Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134824474-134825331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134825332-134826188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134826189-134827045 Neighboring gene MPRA-validated peak5480 silencer Neighboring gene Sharpr-MPRA regulatory region 242 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134871641-134872156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134877514-134878015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134878708-134879599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134879600-134880490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134880491-134881382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:134900858-134901378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134904009-134904938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134905671-134906171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134920433-134920934 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134938767-134939339 Neighboring gene solute carrier family 25 member 48 Neighboring gene C-X-C motif chemokine ligand 14 Neighboring gene SLC25A48 antisense RNA 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in auditory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cochlea development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cochlea morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in craniofacial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in exit from mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in genitalia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hard palate morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in inner ear development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in learned vocalization behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mastication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of relaxation of muscle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of saliva secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peristalsis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of exit from mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of muscle organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thorax and anterior abdomen determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in trigeminal nerve development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vestibulocochlear nerve formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurogenin-1
    Names
    NGN-1
    class A basic helix-loop-helix protein 6
    neurogenic basic-helix-loop-helix protein
    neurogenic differentiation 3
    neurogenic differentiation factor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006161.3NP_006152.2  neurogenin-1

      See identical proteins and their annotated locations for NP_006152.2

      Status: VALIDATED

      Source sequence(s)
      AC005738, BC028226
      Consensus CDS
      CCDS4187.1
      UniProtKB/Swiss-Prot
      Q5U0Q9, Q92886, Q96HE1
      UniProtKB/TrEMBL
      B2RAP3, F1T0H3
      Related
      ENSP00000317580.4, ENST00000314744.6
      Conserved Domains (1) summary
      cd00083
      Location:90149
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      135534282..135535964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      136061404..136063086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)