U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from OMIM

    • Showing Current items.

    ZNF507 zinc finger protein 507 [ Homo sapiens (human) ]

    Gene ID: 22847, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF507provided by HGNC
    Official Full Name
    zinc finger protein 507provided by HGNC
    Primary source
    HGNC:HGNC:23783
    See related
    Ensembl:ENSG00000168813 MIM:620567; AllianceGenome:HGNC:23783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp507
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 9.1), thyroid (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZNF507 in Genome Data Viewer
    Location:
    19q13.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (32345610..32387667)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (34864228..34906309)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (32836516..32878573)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 472 Neighboring gene uncharacterized LOC124904688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10479 Neighboring gene uncharacterized LOC124904689 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:32845640-32845808 Neighboring gene Sharpr-MPRA regulatory region 4314 Neighboring gene DPY19L3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10481 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:32911836-32912044 Neighboring gene dpy-19 like C-mannosyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14429

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state. Kwon W, et al. J Exp Clin Cancer Res, 2021 Sep 18. PMID 34537073, Free PMC Article
    2. ZNF146/OZF and ZNF507 target LINE-1 sequences. Creamer KM, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100360, Free PMC Article
    3. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. Funato Y, et al. Dev Cell, 2020 Nov 23. PMID 32918875
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Kikuno R, et al. DNA Res, 1999 Jun 30. PMID 10470851
    5. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. Georges A, et al. Sci Rep, 2019 Feb 25. PMID 30804394, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF146/OZF and ZNF507 target LINE-1 sequences.
      Title: ZNF146/OZF and ZNF507 target LINE-1 sequences.
    2. ZNF507 affects TGF-beta signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.
      Title: ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 507

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136156.2 → NP_001129628.1  zinc finger protein 507

      See identical proteins and their annotated locations for NP_001129628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007773, AL713775, BU681879, BX640881, CK820221, DB165165
      Consensus CDS
      CCDS32985.1
      UniProtKB/Swiss-Prot
      A8K911, Q2TBF1, Q6MZU0, Q8TCN5, Q9UPR8
      UniProtKB/TrEMBL
      B9EGE7
      Related
      ENSP00000348162.4, ENST00000355898.6
      Conserved Domains (2) summary
      sd00017
      Location:643 → 663
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:773 → 797
      zf-H2C2_2; Zinc-finger double domain

    2. NM_014910.5 → NP_055725.2  zinc finger protein 507

      See identical proteins and their annotated locations for NP_055725.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC007773, BU681879, BX640881, CK820221, DB165165
      Consensus CDS
      CCDS32985.1
      UniProtKB/Swiss-Prot
      A8K911, Q2TBF1, Q6MZU0, Q8TCN5, Q9UPR8
      UniProtKB/TrEMBL
      B9EGE7
      Related
      ENSP00000312277.2, ENST00000311921.8
      Conserved Domains (2) summary
      sd00017
      Location:643 → 663
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:773 → 797
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      32345610..32387667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      34864228..34906309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCN5.2 GenPept UniProtKB/Swiss-Prot:Q8TCN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools