EIF1B eukaryotic translation initiation factor 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF1Bprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 1Bprovided by HGNC
Primary source: HGNC:HGNC:30792
See related: Ensembl:ENSG00000114784 AllianceGenome:HGNC:30792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GC20
Summary: Enables RNA binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart (RPKM 113.1), bone marrow (RPKM 72.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (40309707..40312424)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (40324755..40327472)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (40351198..40353915)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EIF1B (e-PCR)
- UniSTS:505204

SHGC-76854 (e-PCR)
- UniSTS:36032

GC20 (e-PCR)
- UniSTS:278469

MARC_2151-2152:991932527:1 (e-PCR)
- UniSTS:230907

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 1b

Names: protein translation factor SUI1 homolog GC20; translation factor sui1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.