U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MIR148A microRNA 148a [ Homo sapiens (human) ]

    Gene ID: 406940, updated on 10-Dec-2024

    Summary

    Official Symbol
    MIR148Aprovided by HGNC
    Official Full Name
    microRNA 148aprovided by HGNC
    Primary source
    HGNC:HGNC:31535
    See related
    Ensembl:ENSG00000199085 MIM:613786; miRBase:MI0000253; AllianceGenome:HGNC:31535
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRN148; MIRN148A; mir-148a; hsa-mir-148
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MIR148A in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (25949919..25949986, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (26085385..26085452, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (25989539..25989606, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18026 Neighboring gene VISTA enhancer hs1465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25772 Neighboring gene uncharacterized LOC105375199 Neighboring gene uncharacterized LOC105375200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25776 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:26050032-26050705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25777 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:26140958-26141128 Neighboring gene uncharacterized LOC105375198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25778 Neighboring gene MPRA-validated peak6446 silencer Neighboring gene MPRA-validated peak6447 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:26187424-26188096 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:26188097-26188769 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:26191778-26192572 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr7:26192573-26193366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:26197976-26198476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:26198477-26198977 Neighboring gene Sharpr-MPRA regulatory region 12991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25783 Neighboring gene Sharpr-MPRA regulatory region 4449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25785 Neighboring gene NFE2 like bZIP transcription factor 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    General gene information

    Other Names

    • hsa-mir-148a
    • microRNA 148

    Gene Ontology Provided by GOA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_029597.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC010719
      Related
      ENST00000362215.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      25949919..25949986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      26085385..26085452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)