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    NDN necdin, MAGE family member [ Homo sapiens (human) ]

    Gene ID: 4692, updated on 10-Dec-2024

    Summary

    Official Symbol
    NDNprovided by HGNC
    Official Full Name
    necdin, MAGE family memberprovided by HGNC
    Primary source
    HGNC:HGNC:7675
    See related
    Ensembl:ENSG00000182636 MIM:602117; AllianceGenome:HGNC:7675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PWCR; HsT16328
    Summary
    This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See NDN in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (23685400..23687305, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (21419888..21421793, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (23930547..23932452, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903576 Neighboring gene NANOG hESC enhancer GRCh37_chr15:23873940-23874461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23891457-23892301 Neighboring gene MAGE family member L2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23959525-23960135 Neighboring gene uncharacterized LOC124903577 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:24001764-24002963 Neighboring gene RNA, U6 small nuclear 741, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-04-26)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-04-26)

    ClinGen Genome Curation Page

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in genomic imprinting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organismal-level homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    necdin
    Names
    Prader-Willi syndrome chromosome region
    necdin homolog
    necdin, melanoma antigen (MAGE) family member
    necdin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009380.1 RefSeqGene

      Range
      4999..6904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1047

    mRNA and Protein(s)

    1. NM_002487.3NP_002478.1  necdin

      See identical proteins and their annotated locations for NP_002478.1

      Status: REVIEWED

      Source sequence(s)
      AC124309
      Consensus CDS
      CCDS10014.1
      UniProtKB/Swiss-Prot
      B2R6Z5, Q99608
      UniProtKB/TrEMBL
      X5D982
      Related
      ENSP00000497916.1, ENST00000649030.2
      Conserved Domains (1) summary
      pfam01454
      Location:105273
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      23685400..23687305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      4633210..4635115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      21419888..21421793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)