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    ZNF287 zinc finger protein 287 [ Homo sapiens (human) ]

    Gene ID: 57336, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZNF287provided by HGNC
    Official Full Name
    zinc finger protein 287provided by HGNC
    Primary source
    HGNC:HGNC:13502
    See related
    Ensembl:ENSG00000141040 AllianceGenome:HGNC:13502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN45; ZKSCAN13
    Summary
    This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 1.8), thyroid (RPKM 1.4) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF287 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16546954..16569212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16449237..16471499, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16450268..16472526, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903940 Neighboring gene uncharacterized LOC124903941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11768 Neighboring gene uncharacterized LOC105371554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16471581-16472082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16472083-16472582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11769 Neighboring gene zinc finger protein 624 Neighboring gene SRSF6 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16556408-16556918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8228 Neighboring gene uncharacterized LOC124903934

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126536, MGC141923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 287
    Names
    zinc finger protein with KRAB and SCAN domains 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051652.1 RefSeqGene

      Range
      5009..27259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346167.2NP_001333096.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Conserved Domains (5) summary
      smart00349
      Location:170227
      KRAB; krueppel associated box
      COG5048
      Location:422755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46144
      SCAN; SCAN oligomerization domain
    2. NM_001346168.2NP_001333097.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Conserved Domains (5) summary
      smart00349
      Location:170227
      KRAB; krueppel associated box
      COG5048
      Location:422755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46144
      SCAN; SCAN oligomerization domain
    3. NM_001346169.2NP_001333098.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Related
      ENSP00000379168.1, ENST00000395824.5
      Conserved Domains (5) summary
      smart00349
      Location:170227
      KRAB; krueppel associated box
      COG5048
      Location:422755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46144
      SCAN; SCAN oligomerization domain
    4. NM_001346170.1NP_001333099.1  zinc finger protein 287 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC127540
    5. NM_001346171.2NP_001333100.1  zinc finger protein 287 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC127540
    6. NM_020653.4NP_065704.2  zinc finger protein 287 isoform a

      See identical proteins and their annotated locations for NP_065704.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540, BC057791, DA103127
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Related
      ENSP00000379169.3, ENST00000395825.4
      Conserved Domains (5) summary
      smart00349
      Location:170227
      KRAB; krueppel associated box
      COG5048
      Location:422755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46144
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      16546954..16569212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      16449237..16471499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)