STAM signal transducing adaptor molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: STAMprovided by HGNC
Official Full Name: signal transducing adaptor moleculeprovided by HGNC
Primary source: HGNC:HGNC:11357
See related: Ensembl:ENSG00000136738 MIM:601899; AllianceGenome:HGNC:11357
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STAM1; STAM-1
Summary: This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p12.33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (17644151..17716824)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (17662652..17736129)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (17686150..17758823)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme.
Title: A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme.
A non-GPCR-binding partner interacts with a novel surface on beta-arrestin1 to mediate GPCR signaling.
Title: A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner.
Title: β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains
Title: The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.
Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
Title: Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Title: ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Overexpression of an AIP4 catalytically inactive mutant and a mutant that shows poor binding to STAM-1 fails to enhance CXCR4-induced ERK-1/2 signaling.
Title: Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed.
Title: Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy.
STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
Title: STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-83385 (e-PCR)
- UniSTS:101894

STAM_850 (e-PCR)
- UniSTS:277771

STAM_V162 (e-PCR)
- UniSTS:277771

RH45982 (e-PCR)
- UniSTS:59930

G22042 (e-PCR)
- UniSTS:17527

RH70633 (e-PCR)
- UniSTS:71593

RH46555 (e-PCR)
- UniSTS:52653

STS-H94886 (e-PCR)
- UniSTS:52917

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in macroautophagy	TAS Traceable Author Statement more info	PubMed
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of extracellular exosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT-0 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT-0 complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT-0 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ESCRT-0 complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: signal transducing adapter molecule 1

Names: HSE1 homolog; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324282.2 → NP_001311211.1 signal transducing adapter molecule 1 isoform e

Status: REVIEWED

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B2RAY1
NM_001324283.2 → NP_001311212.1 signal transducing adapter molecule 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B2RAY1

Conserved Domains (3) summary

cd11964
Location:163 → 217

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

pfam03127
Location:256 → 327

GAT; GAT domain

cl02544
Location:1 → 92

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001324284.2 → NP_001311213.1 signal transducing adapter molecule 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B2RAY1

Conserved Domains (3) summary

cd11964
Location:163 → 217

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

pfam03127
Location:256 → 327

GAT; GAT domain

cl02544
Location:1 → 92

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001324285.2 → NP_001311214.1 signal transducing adapter molecule 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B2RAY1

Conserved Domains (3) summary

cd11964
Location:163 → 217

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

pfam03127
Location:256 → 327

GAT; GAT domain

cl02544
Location:1 → 92

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001324286.2 → NP_001311215.1 signal transducing adapter molecule 1 isoform d

Status: REVIEWED

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B2RAY1
NM_001324287.2 → NP_001311216.1 signal transducing adapter molecule 1 isoform b

Status: REVIEWED

Source sequence(s)

AC069542

UniProtKB/TrEMBL

B4DZT2

Conserved Domains (3) summary

cd11964
Location:102 → 156

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

pfam03127
Location:195 → 266

GAT; GAT domain

cl02544
Location:1 → 31

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
NM_001324288.2 → NP_001311217.1 signal transducing adapter molecule 1 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (8) and variant 9 both encode isoform f.

Source sequence(s)

AC069542
NM_001324289.2 → NP_001311218.1 signal transducing adapter molecule 1 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (9) and variant 8 both encode isoform f.

Source sequence(s)

AC069542
NM_003473.4 → NP_003464.1 signal transducing adapter molecule 1 isoform a

See identical proteins and their annotated locations for NP_003464.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC069542, AU118708, U43899

Consensus CDS

CCDS7122.1

UniProtKB/Swiss-Prot

B0YJ99, D3DRU5, Q8N6D9, Q92783

UniProtKB/TrEMBL

B2RAY1

Related

ENSP00000366746.3, ENST00000377524.8

Conserved Domains (3) summary

cd11964
Location:213 → 267

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

cd17000
Location:9 → 139

VHS_STAM1; VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1

cd21389
Location:301 → 377

GAT_STAM1; non-canonical GAT domain found in signal transducing adapter molecule 1 (STAM-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

17644151..17716824

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011519695.4 → XP_011517997.1 signal transducing adapter molecule 1 isoform X1

UniProtKB/TrEMBL

B2RAY1

Conserved Domains (3) summary

cd11964
Location:213 → 267

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

cd03568
Location:9 → 142

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam03127
Location:306 → 377

GAT; GAT domain