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    PLA2G10 phospholipase A2 group X [ Homo sapiens (human) ]

    Gene ID: 8399, updated on 10-Dec-2024

    Summary

    Official Symbol
    PLA2G10provided by HGNC
    Official Full Name
    phospholipase A2 group Xprovided by HGNC
    Primary source
    HGNC:HGNC:9029
    See related
    Ensembl:ENSG00000069764 MIM:603603; AllianceGenome:HGNC:9029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPLA2; GXPLA2; GXSPLA2; sPLA2-X
    Summary
    This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLA2G10 in Genome Data Viewer
    Location:
    16p13.12-p13.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14672548..14701850, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14766405..14788430, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene poly(A)-specific ribonuclease Neighboring gene RNA, 7SL, cytoplasmic 274, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14723085-14723608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14723609-14724130 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14724131-14724653 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14726253-14726820 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14726821-14727390 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:14730046-14730899 Neighboring gene RNA, U7 small nuclear 125 pseudogene Neighboring gene bifunctional apoptosis regulator Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14781374-14781874 Neighboring gene group 10 secretory phospholipase A2 Neighboring gene nuclear pore complex interacting protein family member A3 Neighboring gene nuclear pore complex interacting protein family member A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env sPLA(2)-X neutralizes human immunodeficiency virus type 1 (HIV-1) through degradation of the viral membrane (gp120) and inhibits the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4(+) T cells PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119918, MGC119919, MGC133367

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lysophospholipid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylserine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activating factor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of acrosome reaction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of arachidonate secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of prostaglandin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in production of molecular mediator involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    group 10 secretory phospholipase A2
    Names
    group X secretory phospholipase A2
    phosphatidylcholine 2-acylhydrolase 10
    NP_003552.1
    XP_011520997.1
    XP_011520998.1
    XP_011520999.1
    XP_011521000.1
    XP_047290713.1
    XP_054185113.1
    XP_054185114.1
    XP_054185115.1
    XP_054185116.1
    XP_054185117.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003561.3NP_003552.1  group 10 secretory phospholipase A2 preproprotein

      See identical proteins and their annotated locations for NP_003552.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      U95301
      Consensus CDS
      CCDS10555.1
      UniProtKB/Swiss-Prot
      O15496, Q14DU3, Q6NT23
      Related
      ENSP00000393847.4, ENST00000438167.8
      Conserved Domains (1) summary
      cd00125
      Location:43157
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

    RNA

    1. NR_133651.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BM739473, U95301

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      14672548..14701850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434757.1XP_047290713.1  group 10 secretory phospholipase A2 isoform X1

      UniProtKB/Swiss-Prot
      O15496, Q14DU3, Q6NT23
    2. XM_011522697.3XP_011520999.1  group 10 secretory phospholipase A2 isoform X4

      See identical proteins and their annotated locations for XP_011520999.1

      UniProtKB/TrEMBL
      H3BRW4
      Related
      ENSP00000456433.1, ENST00000567462.1
      Conserved Domains (1) summary
      cd00125
      Location:43119
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    3. XM_011522695.4XP_011520997.1  group 10 secretory phospholipase A2 isoform X2

      See identical proteins and their annotated locations for XP_011520997.1

      UniProtKB/TrEMBL
      H3BRW4
      Conserved Domains (1) summary
      cd00125
      Location:43122
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    4. XM_011522696.4XP_011520998.1  group 10 secretory phospholipase A2 isoform X3

      See identical proteins and their annotated locations for XP_011520998.1

      UniProtKB/TrEMBL
      H3BRW4
      Conserved Domains (1) summary
      cd00125
      Location:43118
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    5. XM_011522698.3XP_011521000.1  group 10 secretory phospholipase A2 isoform X5

      See identical proteins and their annotated locations for XP_011521000.1

      UniProtKB/TrEMBL
      H3BRW4
      Conserved Domains (1) summary
      cd00125
      Location:43119
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      245407..274712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329138.1XP_054185113.1  group 10 secretory phospholipase A2 isoform X1

      UniProtKB/Swiss-Prot
      O15496, Q14DU3, Q6NT23
    2. XM_054329141.1XP_054185116.1  group 10 secretory phospholipase A2 isoform X4

      UniProtKB/TrEMBL
      H3BRW4
    3. XM_054329139.1XP_054185114.1  group 10 secretory phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      H3BRW4
    4. XM_054329140.1XP_054185115.1  group 10 secretory phospholipase A2 isoform X3

      UniProtKB/TrEMBL
      H3BRW4
    5. XM_054329142.1XP_054185117.1  group 10 secretory phospholipase A2 isoform X5

      UniProtKB/TrEMBL
      H3BRW4