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| Status |
Public on Jun 10, 2019 |
| Title |
Comparison of 7 small cell lung cancer PDX models, cultured ex vivo, for response to LSD1 inhibitor RG6016/ORY1001 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of this study was to understand how the LSD1 inhibitor RG6016/ORY1001 leads to selective efficacy in subsets of small cell lung cancer. SCLC cell lines, PDX models studied ex vivo and studied in vivo were employed in this analysis
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| |
|
| Overall design |
SCLC PDX models were transiently cultured and exposed to saline vehicle or 1nM RG6016/ORY1001 for 48 hours. RNA was isolated and RNA-seq analyses performed
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| |
|
| Contributor(s) |
MacPherson D, Augert A |
| Citation(s) |
30723171 |
| |
| Submission date |
Aug 25, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
David MacPherson |
| Organization name |
Fred Hutchinson Cancer Research Center
|
| Street address |
1100 Fairview Ave N
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE103097 |
Small cell lung cancer PDX model response to LSD1 inhibitor RG6016/ORY1001 |
|
| Relations |
| BioProject |
PRJNA400281 |
| SRA |
SRP116256 |
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