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| Status |
Public on Jan 08, 2018 |
| Title |
Epigenomes and transcriptomes of human monocytes before and after in vivo exposure to Bacillus Calmette-Guérin vaccine |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components. In this study, we apply epigenomic and transcriptomic analysis to a clinical trial of BCG vaccination in healthy adults.
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| |
|
| Overall design |
Healthy volunteers were injected with the BCG vaccine, and monocytes were collected before vaccination, and 1 month after vaccination.
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| |
|
| Contributor(s) |
Arts RJ, Moorlag S, Novakovic B, Netea M |
| Citation(s) |
29324233, 31671203 |
| |
| Submission date |
Sep 22, 2017 |
| Last update date |
Mar 20, 2023 |
| Contact name |
Boris Novakovic |
| E-mail(s) |
[email protected]
|
| Phone |
0434980073
|
| Organization name |
Murdoch Children's Research Institute
|
| Street address |
Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road
|
| City |
Parkville |
| State/province |
Victoria |
| ZIP/Postal code |
3052 |
| Country |
Australia |
| |
|
| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (26)
|
|
| Relations |
| BioProject |
PRJNA411820 |
| SRA |
SRP118694 |
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