|
| Status |
Public on Jun 09, 2018 |
| Title |
Identification of chloroquine diphosphate as an autophagy inhibitor to treat PANC-1 cells [mRNA, circRNA, lncRNA] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
Autophagy has been reported to be involved in the occurrence and development of pancreatic cancer. However, the mechanism of autophagy-related non-coding RNAs in pancreatic cancer remains largely unknown. In this study, we used microarrays to detect differential expression of mRNAs, miRNAs, lncRNAs and circRNAs post autophagy suppression by chloroquine diphosphate in PANC-1 cells.
|
| |
|
| Overall design |
The autophagy-inhibited model was constructed with PANC-1 cells treated by chloroquine diphosphate. It was indicated that 100µM chloroquine diphosphate was the best choice to inhibit the autophagy of PANC-1 in humans.
|
| |
|
| Contributor(s) |
Wei D, Jiang M, Lin P, Yang H, Dang Y, Yu Q, Liao D, Luo D, Chen G |
| Citation(s) |
30570107 |
| |
| Submission date |
Jun 08, 2018 |
| Last update date |
Feb 20, 2019 |
| Contact name |
Qiao Yu |
| E-mail(s) |
[email protected]
|
| Phone |
15177910671
|
| Organization name |
First Affiliated Hospital of Guangxi Medical University
|
| Street address |
Shuangyong road, qingxiu district，nanning
|
| City |
Nanning |
| ZIP/Postal code |
530021 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL22120 |
Agilent-078298 human ceRNA array V1.0 4X180K [Probe Name Version] |
|
| Samples (2) |
|
| This SubSeries is part of SuperSeries: |
| GSE115517 |
Identification of chloroquine diphosphate as an autophagy inhibitor to treat PANC-1 cells |
|
| Relations |
| BioProject |
PRJNA475251 |
