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Series GSE121633 Query DataSets for GSE121633
Status Public on Nov 25, 2018
Title Epigenetic findings in periodontitis in UK twins: a cross sectional study
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease.
 
Overall design Self-reported gum bleeding and tooth mobility were used as indicators of periodontal disease. DNA methylation profiles were generated using the Infinium HumanMethylation450 BeadChip in whole blood, buccal, and adipose samples from predominantly older female twins (mean age 58) from the TwinsUK cohort. Epigenome-wide association scans (EWAS) of gum bleeding and tooth mobility were conducted in whole blood in 528 and 492 twins, respectively. Subsequently, 28 genomic signals were explored for phenotype- methylation associations in 41 (Tooth mobility) and 43 (Gum bleeding) buccal samples, and 501 (Tooth mobility) and 556 (Gum bleeding) adipose DNA samples.
 
Contributor(s) Kurushima Y, Tsai P, Castillo-Fernandez J, Cuoto Alves A, El-Sayed Moustafa JS, Le Roy C, Ide M, Hughes F, Small K, Steves CJ, Bell JT
Citation(s) 30760334
Submission date Oct 22, 2018
Last update date Jan 25, 2021
Contact name Juan Castillo-Fernandez
E-mail(s) [email protected]
Organization name King's College London
Department Department of Twin Research
Lab Epigenetics
Street address St Thomas Hospital
City London
ZIP/Postal code SE1 7EH
Country United Kingdom
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (480)
GSM3440311 ERC45KI21 genomic DNA from whole blood
GSM3440312 ERC45KI62 genomic DNA from whole blood
GSM3440313 ERC45KI81 genomic DNA from whole blood
Relations
BioProject PRJNA497900

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121633_RAW.tar 4.0 Gb (http)(custom) TAR (of IDAT)
GSE121633_methylation.txt.gz 1.6 Gb (ftp)(http) TXT
Processed data are available on Series record
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