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| Status |
Public on Mar 13, 2009 |
| Title |
Rat exposure to RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr) |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. The objective of this study was to examine the effect of a single oral dose of RDX on global gene expression in the mammalian brain and liver, using a rodent model.
Keywords: time course, dose response
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| Overall design |
Male Sprague-Dawley rats were given a single, oral, non-seizure inducing dose of either 3 or 18 mg/kg RDX in a gel capsule. Rats were euthanized at times 0, 4, 24, and 48 hours. RNA purified from brain cortex or liver was hybridized to Affymetrix rat 230.2 arrays.
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| Contributor(s) |
Bannon D, Dillman J, Perkins E |
| Citation(s) |
19239275 |
| |
| Submission date |
Jul 22, 2008 |
| Last update date |
Jul 31, 2017 |
| Contact name |
James F Dillman |
| E-mail(s) |
[email protected]
|
| Phone |
4104361723
|
| Organization name |
U.S. Army Medical Research Institute of Chemical Defense
|
| Department |
Cell and Molecular Biology Branch
|
| Lab |
Molecular Toxicology Team
|
| Street address |
3100 Ricketts Point Rd
|
| City |
Aberdeen Proving Ground |
| State/province |
MD |
| ZIP/Postal code |
21010-5400 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA113417 |
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