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Series GSE12761 Query DataSets for GSE12761
Status Public on Sep 02, 2009
Title Co-amplification at 8p and 11q in breast tumors and cell lines with 8p11q array Genomic Comparative Hybridization
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Co-amplification at chromosomes 8p11-8p12 and 11q12-11q14 occurs often in breast tumors, suggesting possible cooperation between genes in these regions in oncogenesis. We used high resolution array comparative genomic hybridization (array CGH) to map the minimal amplified regions. The 8p and 11q amplicons are complex and consist of at least four amplicon cores at each site. Candidate genes mapping to these regions were identified by combining copy number and RNA and protein expression analyses. Funcational analysis for transformation was further carried out with candidate genes to determine candidate oncogenes.
 
Overall design Near tiling path coverage of 8p11q array CGH experiments with breast cell lines and ductal invasive and lymph node-negative breast tumors.
 
Contributor(s) Kwek SS, Albertson DG, Climent J, Martinez-Climent JA
Citation(s) 19330026
Submission date Sep 12, 2008
Last update date Mar 20, 2012
Contact name Serena S kwek
E-mail(s) [email protected]
Phone 415-514-9301
Organization name UCSF
Department Cancer Research Institute
Lab Donna Albertson
Street address 2340 Sutter St.
City San Francsico
State/province CA
ZIP/Postal code 94143-0808
Country USA
 
Platforms (1)
GPL7298 UCSF Homo sapiens CGH 8p11q
Samples (42)
GSM320171 Breast cell line MCF10A
GSM320172 Breast cell line MCF7
GSM320173 Breast cell line BT474
Relations
BioProject PRJNA111019

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12761_RAW.tar 5.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file
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