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Series GSE1297 Query DataSets for GSE1297
Status Public on Jul 16, 2004
Title Incipient Alzheimer's Disease: Microarray Correlation Analyses
Organism Homo sapiens
Experiment type Expression profiling by array
Summary For these data, we analyzed hippocampal gene expression of nine control and 22 AD subjects of varying severity on 31 separate microarrays. We then tested the correlation of each gene's expression with MiniMental Status Examination (MMSE) and neurofibrillary tangle (NFT) scores across all 31 subjects regardless of diagnosis. These tests revealed a major transcriptional response comprising thousands of genes significantly correlated with AD markers. Several hundred of these genes were also correlated with AD markers across only control and incipient AD subjects (MMSE > 20).
Keywords = bioinformatics
Keywords = gene expression
Keywords = memory
Keywords = synaptic plasticity
Keywords = myelin
Keywords = inflamation
Keywords = aging
Keywords = behavior
Keywords = Alzheimer's
Keywords = microarray
Keywords: repeat sample
 
 
Contributor(s) Blalock EM, Geddes JW, Chen K, Porter NM, Markesbery WR, Landfield PW
Citation(s) 14769913
Submission date Apr 08, 2004
Last update date Aug 10, 2018
Contact name Eric M Blalock
E-mail(s) [email protected]
Phone 859-323-8033
Organization name University of Kentucky
Department Molecular and Biomedical Pharmacology
Lab Blalock
Street address 800 Rose St.
City Lexington
State/province KY
ZIP/Postal code 40475
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (31)
GSM21203 Severe 701
GSM21204 Incipient 715
GSM21205 Incipient 720
Relations
BioProject PRJNA90219

Subject characteristics for Human Alzheimer's Study header descriptions
ref number
Group
NFT
BRAAK
Age
MMSE
Sex
PMI

Data table
ref number Group NFT BRAAK Age MMSE Sex PMI
976 Control 8 3 85 30 M 2
1008 Control 2 2 92 26 F 2.45
1012 Control 0.4 4 80 26 M 3
1015 Control 0.4 1 75 29 M 3.35
1018 Control 4.8 3 97 29 F 2.75
1030 Control 0 1 95 28 M 1.75
1039 Control 0.3 1 77 28 M 3.5
1040 Control 1.3 2 87 27 M 2
1003 Control 7 2 80 26 M 2.25
720 Incipient 12 6 95 29 F 6.17
715 Incipient 65.8 5 101 25 F 1.35
994 Incipient 6.4 5 83 26 F 2.25
1019 Incipient 5.5 6 88 24 M 2.75
1029 Incipient 7.2 3 91 25 F 4
1034 Incipient 17.4 5 88 20 M 2.75
1043 Incipient 8 5 97 21 F 4
1031 Moderate 13.8 6 86 15 F 4.25
826 Moderate 35.2 6 85 18 F 2.92
832 Moderate 19 5 89 15 F 2.63
856 Moderate 42 5 83 17 F 2.53

Total number of rows: 31

Table truncated, full table size <1 Kbytes.




Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE1297_RAW.tar 109.6 Mb (http)(custom) TAR (of CEL, EXP, RPT, TXT)

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