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| Status |
Public on Jan 31, 2020 |
| Title |
Effect of knocking down complex I subunit nuo-5 (ortholog of the human NDUFS1) in C.elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
In this study we compared the transcriptomic profile in control L3 larvae with that of mild or strong (arrested) nuo-5 RNAi. The two treatment (mild and strong) in fact lead to two very different phenotype. The mild supperssion of nuo-5 induces improved healthspand and has pro longevity effect. The strong suppression of the same gene has, on the contrary, deleterious effects such as arrested development.
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| Overall design |
Three different groups were analyzed, each containing 4 independent samples
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| Contributor(s) |
Maglioni S, Ventura N, Schiavi A |
| Citation(s) |
35551180 |
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Silvia Maglioni, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Nuno Raimundo, Anna Laromaine, Joel N Meyer, Felix Distelmaier, and Natascia Ventura. Lutein restores synaptic functionality in a C. elegans model for mitochondrial complex I deficiency. bioRxiv 2020.02.20.957225. doi:10.1101/2020.02.20.957225
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| Submission date |
Jan 30, 2020 |
| Last update date |
May 25, 2022 |
| Contact name |
Silvia Maglioni |
| E-mail(s) |
[email protected]
|
| Organization name |
IUF-Leibniz Institute
|
| Street address |
Auf' m hennekamp 50
|
| City |
Düsseldorf |
| State/province |
NRW |
| ZIP/Postal code |
40468 |
| Country |
Germany |
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| Platforms (1) |
| GPL19230 |
[EleGene-1_0-st] Affymetrix C. elegans Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA604038 |
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