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| Status |
Public on Jan 31, 2020 |
| Title |
Effect of lutein on worms lacking complex I subunit nuo-5 (ortholog of human NDUFS1) |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
To gain insight into the pathways accounting for the deleterious effects associated with severe mitochondrial dysfunction, we compared the transcriptomic profile in control L3 larvae with that of strong (arrested) nuo-5 RNAi. We also found that the natural compound lutein was able to rescue some of the defective phenotypes we characterized in nuo-5-depleted animals therefore we compared also the transcriptomic profile of stage-matched (L3) cohorts of C. elegans upon strong nuo-5 RNAi, treated and untreated with lutein, with that of animals fed empty vector control.
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| Overall design |
Three different groups were analyzed, each containing 4 independent samples
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| Contributor(s) |
Maglioni S, Ventura N, Raimundo N |
| Citation(s) |
35551180 |
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Silvia Maglioni, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Nuno Raimundo, Anna Laromaine, Joel N Meyer, Felix Distelmaier, and Natascia Ventura. Lutein restores synaptic functionality in a C. elegans model for mitochondrial complex I deficiency. bioRxiv 2020.02.20.957225. doi:10.1101/2020.02.20.957225
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| Submission date |
Jan 30, 2020 |
| Last update date |
May 25, 2022 |
| Contact name |
Silvia Maglioni |
| E-mail(s) |
[email protected]
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| Organization name |
IUF-Leibniz Institute
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| Street address |
Auf' m hennekamp 50
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| City |
Düsseldorf |
| State/province |
NRW |
| ZIP/Postal code |
40468 |
| Country |
Germany |
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| Platforms (1) |
| GPL19230 |
[EleGene-1_0-st] Affymetrix C. elegans Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA604037 |
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