We here used whole blood gene expression profiling to differentiate SSc patients from healthy controls (HC) and to identify a specific gene expression and predictive genes for SSc-overlap syndromes.
Overall design
For each collection, 2,5ml of peripheral whole blood of 150 SSc patients and 40 HC was drawn into 2 PAXGene Blood RNA tubes of PreAnalytiX (Qiagen, BD Company, Hilden, Germany). Gene expression analysis was performed using the Affymetrix Human Genome U219 Chip.
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