|
| Status |
Public on Nov 30, 2020 |
| Title |
The effect of IFNAR1 blockade on Tfh-cell production of IL-21 and IFN-γ loci |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
To determine if the effect of IFNAR1 blockade on Tfh-cell production of IL-21 and IFN-γ was a consequence of altered chromatin accessibility, we used ATAC-seq to characterize their gene loci.
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| |
|
| Overall design |
Sorted Tfh cells (CD4+CD44+GITR-PSGL-1loCXCR5hiPD-1hi) from 5-month old B6/Sle1.Yaa mice treated twice a week for 4 weeks with either anti-IFNA1 or anti-rat IgG
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| |
|
| Contributor(s) |
Weinstein J, Lemenze A |
| Citation(s) |
33512094 |
| |
| Submission date |
Aug 20, 2020 |
| Last update date |
Mar 01, 2021 |
| Contact name |
Jason Weinstein |
| E-mail(s) |
[email protected]
|
| Phone |
9739723161
|
| Organization name |
Rutgers New Jersey Medical School
|
| Department |
Center for Immunity and Inflmmation
|
| Street address |
New Jersey Medical School Cancer Center 205 South Orange Ave
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (7)
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|
| Relations |
| BioProject |
PRJNA658366 |
| SRA |
SRP278248 |
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