|
| Status |
Public on Feb 13, 2021 |
| Title |
Single Cell Profiling Identifies the Histone Demethylase, JMJD3, Modulates Macrophage Phenotype in Abdominal Aortic Aneurysm Formation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Abdominal aortic aneurysm (AAA) is a life-threatening disease characterized by an inflammatory macrophage phenotype that contributes to pathological vascular remodeling. Although the mechanisms regulating macrophage-mediated inflammation during AAA development remain undefined, accumulating evidence suggests that epigenetic alterations play a critical role. Here using single cell RNA-sequencing techniques, we identify that the histone demethylase JMJD3 is elevated in human AAA monocytes/macrophages, resulting in the upregulation of cellular activation and a proinflammatory immune response.
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| |
|
| Overall design |
scRNA-seq for AAA
|
| |
|
| Contributor(s) |
Davis FM, Tsoi LC, Gudjonsson JE, Gallagher KA |
| Citation(s) |
33779682 |
| |
| Submission date |
Feb 12, 2021 |
| Last update date |
May 15, 2021 |
| Contact name |
Lam Tsoi |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Michigan
|
| Street address |
Medical Sciences 1 Bldg. 1301 E. Catherine
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA701583 |
| SRA |
SRP306120 |
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