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| Status |
Public on Dec 15, 2009 |
| Title |
The profile of cellular and KSHV microRNAs in KSHV infected lymphatic endothelial cells (6 and 72 hours post infection) |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions. The disease is caused by the KSHV virus (HHV8) and is recognizable by its distinctive red skin lesions. The lesions are KSHV infected spindle cells, most commonly the lymphatic endothelial and blood vessel endothelial cells (LEC and BEC), plus surrounding stroma. The effects of KSHV infection of LECs were assayed using Affymetrix hgu133plus2 chips at 6 and 72 hours post infection.
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| Overall design |
There were n=4 each of lymphatic endothelial cells (LEC) following 6 hours of culture, LEC following 6 hours post KSHV infection, LEC following 72 hours of culture, and LEC following 72 hours post KSHV infection.
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| Contributor(s) |
Lagos D, Henderson S, Boshoff C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 08, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Stephen Henderson |
| E-mail(s) |
[email protected]
|
| Phone |
02076796827
|
| Fax |
02076796851
|
| Organization name |
UCL
|
| Department |
Cancer Institute
|
| Lab |
Viral Oncology
|
| Street address |
Paul O'Gorman Building, Huntley Street
|
| City |
London |
| ZIP/Postal code |
WC1E 6BT |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL9081 |
Agilent-016436 Human miRNA Microarray 1.0 G4472A (miRNA ID version) |
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| Samples (16)
|
| GSM425692 |
lympatic endothelial cell 6 hours_1 |
| GSM425693 |
lympatic endothelial cell 6 hours_2 |
| GSM425694 |
lympatic endothelial cell 6 hours_3 |
| GSM425695 |
lympatic endothelial cell 6 hours_4 |
| GSM425696 |
lympatic endothelial cell 6 hours post KSHV infection_1 |
| GSM425697 |
lympatic endothelial cell 6 hours post KSHV infection_2 |
| GSM425698 |
lympatic endothelial cell 6 hours post KSHV infection_3 |
| GSM425699 |
lympatic endothelial cell 6 hours post KSHV infection_4 |
| GSM425700 |
lympatic endothelial cell 72 hours_1 |
| GSM425701 |
lympatic endothelial cell 72 hours_2 |
| GSM425702 |
lympatic endothelial cell 72 hours_3 |
| GSM425703 |
lympatic endothelial cell 72 hours_4 |
| GSM425704 |
lympatic endothelial cell 72 hours post KSHV infection_1 |
| GSM425705 |
lympatic endothelial cell 72 hours post KSHV infection_2 |
| GSM425706 |
lympatic endothelial cell 72 hours post KSHV infection_3 |
| GSM425707 |
lympatic endothelial cell 72 hours post KSHV infection_4 |
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| Relations |
| BioProject |
PRJNA117763 |
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