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Series GSE171422 Query DataSets for GSE171422
Status Public on Apr 19, 2022
Title m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [scRNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The function of m6A modification in colonic epithelial cells has been validated in our study that depletion of METTL14 in colonic epithelial cells triggers cell death. To further explore the biological effects of m6A deficiency in colonic epithelial cell heterogeneity, we performed single cell RNA-seq of colonic epithelial cells form 2-week-old Mettl14-KO and WT control mice
 
Overall design Single Cell Profiles of Mettl14 WT and Mettl14 KO colonic epithelial cells of two weeks
 
Contributor(s) Zhang T, Li H
Citation(s)
  • Zhang T, Ding C, Chen H, Zhao J et al. m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway. Sci Adv 2022 Mar 25;8(12):eabl5723. PMID: 35333576
Submission date Apr 03, 2021
Last update date Apr 19, 2022
Contact name Bing Hua Li
E-mail(s) huabing.li@shsmu.edu.cn
Organization name Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine
Street address 280 Chongqing South Rd, Building #5, Room 602, Shanghai
City Shanghai
ZIP/Postal code 200021
Country China
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (2)
GSM5225385 TX1903LHZY1X
GSM5225386 TX1903LHZY2X
This SubSeries is part of SuperSeries:
GSE171423 m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis
Relations
BioProject PRJNA719513
SRA SRP313336

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE171422_cell_metadata.txt.gz 45.8 Kb (ftp)(http) TXT
GSE171422_filtered_gene_count_matrix.txt.gz 22.2 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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